(S)-3-(4-((3-fluoropyrrolidin-1-yl)sulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide

Base Information

• Chemical Name: (S)-3-(4-((3-fluoropyrrolidin-1-yl)sulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide
• CAS No.: 1374986-66-9
• Molecular Formula: C₂₅H₂₅F₂N₃O₅S₂
• Molecular Weight: 549.619
• Mol file: 1374986-66-9.mol

Synonyms:(S)-3-(4-((3-fluoropyrrolidin-1-yl)sulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide

Chemical Property of (S)-3-(4-((3-fluoropyrrolidin-1-yl)sulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(4-((3-fluoropyrrolidin-1-yl)sulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide

There total 3 articles about (S)-3-(4-((3-fluoropyrrolidin-1-yl)sulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-fluoro-1,3-thiazol-2-amine (64588-82-5) + C22H23ClFNO5S → (S)-3-(4-((3-fluoropyrrolidin-1-yl)sulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide (1374986-66-9)

Guidance literature:

With pyridine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.03.008

Reference yield:

C10H11BrFNO2S (1374986-86-3) → (S)-3-(4-((3-fluoropyrrolidin-1-yl)sulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide (1374986-66-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(I) bromide / 1-methyl-pyrrolidin-2-one / 110 °C / Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; water / 2 h / Reflux

3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Reflux

4: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With pyridine; thionyl chloride; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; N,N-dimethyl-formamide; copper(I) bromide; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water;

DOI:10.1016/j.bmc.2012.03.008

Reference yield:

C22H24FNO6S (1393120-62-1) → (S)-3-(4-((3-fluoropyrrolidin-1-yl)sulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide (1374986-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Reflux

2: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With pyridine; thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2012.03.008

upstream raw materials:

5-fluoro-1,3-thiazol-2-amine

C₁₀H₁₁BrFNO₂S

C₂₂H₂₄FNO₆S