64588-82-5

Basic information

• Product Name: 5-fluorothiazol-2-amine
• Synonyms: 2-Thiazolamine, 5-Fluoro-;5-Fluoro-2-Aminothiazol;5-Fluoro-2-thiazolamine;5-fluorothiazol-2-amine;5-Fluoro-thiazol-2-ylaMine;5-Fluoro-2-thiazolaMine hydrochloride;5-Fluoro-2-thiazolaMine h...;2-Amino-5-fluorothiazole hydrochloride
• CAS NO: 64588-82-5
• Molecular Formula: C₃H₃FN₂S
• Molecular Weight: 118
• Mol File: 64588-82-5.mol

Chemical Properties

• Boiling Point: 221.838 °C at 760 mmHg
• Flash Point: 87.965 °C
• Appearance: /
• Density: 1.502 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 5-fluorothiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluorothiazol-2-amine(64588-82-5)
• EPA Substance Registry System: 5-fluorothiazol-2-amine(64588-82-5)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 64588-82-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5-fluorothiazol-2-amine is used as a building block in organic synthesis for the development of pharmaceutical and agrochemical products. Its unique structure allows it to be incorporated into the design and synthesis of new drug candidates, potentially leading to the discovery of novel therapeutic agents.
Used in Medicinal Chemistry Research:
5-fluorothiazol-2-amine is utilized as a research tool in the field of medicinal chemistry. It aids in the synthesis of new compounds and the study of their biological activities, contributing to the advancement of drug discovery and development.
Used in Chemical Reactions and Transformations:
5-fluorothiazol-2-amine may also be employed in the study of chemical reactions and transformations involving thiazole and amine moieties. Its presence in these reactions can provide insights into the reactivity and selectivity of these functional groups, further expanding the understanding of organic chemistry.

Upstream product

• 40283-46-3 2-aminothiazole-5-carboxylic acid 
• 876379-99-6 2-acetamido-5-fluorothiazole 
• 731018-54-5 2-(tert-butoxycarbonyl)amino-5-fluorothiazole 
• 745053-64-9 5-fluoro-1,3-thiazol-2-amine hydrochloride 

Downstream Products

• 1208553-09-6 C₁₄H₁₂ClFN₂OS 
• 1208553-18-7 C₁₅H₁₂F₄N₂OS 
• 1208553-19-8 C₁₅H₁₅FN₂O₃S₂ 
• 1208552-92-4 C₁₅H₁₆ClFN₂OS 
• 1208553-15-4 C₁₃H₁₂ClFN₂OS 
• 1103523-25-6 (S)-2-(4-chlorophenyl)-N-(5-fluorothiazol-2-yl)-3-methylbutanamide 
• 1309612-59-6 C₁₂H₉FN₂O₃S 
• 1336804-28-4 C₁₁H₆FN₃O₂S 
• 1596340-73-6 N-(5-fluorothiazol-2-yl)-3-(4-methanesulfonylphenoxy)-5-(3-methylpyridin-2-yl)benzamide 
• 1282520-13-1 3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide 
• 1374986-68-1 N-(5-fluorothiazol-2-yl)-3-(4-((4-methoxypiperidin-1-yl)sulfonyl)phenoxy)-5-((3-methylbut-2-en-1-yl)oxy)benzamide 
• 1374986-66-9 (S)-3-(4-((3-fluoropyrrolidin-1-yl)sulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide 
• 1374986-58-9 3-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide 
• 1374986-56-7 3-(4-(((2S,6R)-2,6-dimethylmorpholino)sulfonyl)phenoxy)-N-(5-fluorothiazol-2-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide 

Relevant articles and documents

ALPHA-D-GALACTOSIDE INHIBITORS OF GALECTINS

The present invention relates to a compound of the general formula (1). The compound of formula (1) is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-1 to a ligand in a mammal, such as a human. Furthermore, the present invention concerns a method for treatment of a disorder relating to the binding of a galectin, such as galectin-1 to a ligand in a mammal, such as a human.

PROCESS FOR THE PRODUCTION OF 2-AMINO-5-FLUOROTHIAZOLE

A process for the production of fluorinated compound represented by the formula (I): or salts thereof wherein R1 and R2 are the same or different and each is selected from the group consisting of a hydrogen atom, a carbonyl group, a

Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication

We report the syntheses and activities of a wide range of thiazolides [viz., 2-hydroxyaroyl-N-(thiazol-2-yl)amides] against hepatitis B virus replication, with QSAR analysis of our results. The prototypical thiazolide, nitazoxanide [2-hydroxybenzoyl-N-(5-

Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators

A series of N-thiazole substituted arylacetamides were designed on the basis of metabolic mechanism of the aminothiazole fragment as glucokinase (GK) activators for the treatment of type 2 diabetes. Instead of introducing a substituent to block the metabolic sensitive C-5 position on the thiazole core directly, a wide variety of C-4 or both C-4 and C-5 substitutions were explored. Compound R-9k bearing an iso-propyl group as the C-4 substituent was found possessing the highest GK activation potency with an EC50 of 0.026 μM. This compound significantly increased both glucose uptake and glycogen synthesis in rat primary cultured hepatocytes. Moreover, single oral administration of compound R-9k exerted significant reduction of blood glucose levels in both ICR and ob/ob mice. These promising results indicated that compound R-9k is a potent orally active GK activator, and is warranted for further investigation as a new anti-diabetic treatment.

FLUORINATION PROCESS OF PROTECTED AMINOTHIAZOLE

A process for the production of fluorinated compound formula (I) comprising fluorination of a protected aminothiazole. Compounds formula (I) are useful in the preparation of activators of glucokinase.

TRI(CYCLO) SUBSTITUTED AMIDE COMPOUNDS

Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.