C₃₁H₃₇F₂N₅O₅

Base Information

Chemical Name:C₃₁H₃₇F₂N₅O₅
CAS No.:1437787-43-3
Molecular Formula:C₃₁H₃₇F₂N₅O₅
Molecular Weight:597.662
Hs Code.:

C<sub>31</sub>H<sub>37</sub>F<sub>2</sub>N<sub>5</sub>O<sub>5</sub>

Synonyms:C₃₁H₃₇F₂N₅O₅

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Chemical Property of C₃₁H₃₇F₂N₅O₅

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Technology Process of C₃₁H₃₇F₂N₅O₅

There total 5 articles about C₃₁H₃₇F₂N₅O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: C₁₄H₁₄FN₃O₃*ClH

: 1422188-01-9
(R)-tert-butyl 2-((S)-amino(3-fluoro-4-methoxyphenyl)methyl)pyrrolidine-1-carboxylate

: 1437787-43-3
C₃₁H₃₇F₂N₅O₅

Guidance literature:: C₁₄H₁₄FN₃O₃*ClH; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

(R)-tert-butyl 2-((S)-amino(3-fluoro-4-methoxyphenyl)methyl)pyrrolidine-1-carboxylate; In dichloromethane;

Reference yield:

: 252004-45-8
4-chloro- 2,6-difluorobenzaldehyde

: 1437787-43-3
C₃₁H₃₇F₂N₅O₅

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl acetamide / 3 h / 140 °C / Inert atmosphere

2.1: antimony(III) bromide / ethylene dibromide / 0.17 h / 20 °C / Inert atmosphere

2.2: 13 h / 50 °C

3.1: triethylamine / isopropyl alcohol / 2 h / 85 °C / Inert atmosphere

4.1: palladium(II) trifluoroacetate; dicyclohexyl(3-dicyclohexylphosphaniumylpropyl)phosphonium ditetrafluoroborate / 1-methyl-pyrrolidin-2-one / 18 h / 150 °C / Inert atmosphere

4.2: 1 h / 50 °C

4.3: 0.03 h

5.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

With palladium(II) trifluoroacetate; dicyclohexyl(3-dicyclohexylphosphaniumylpropyl)phosphonium ditetrafluoroborate; antimony(III) bromide; triethylamine; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl acetamide; ethylene dibromide; isopropyl alcohol;

Reference yield:

: 1422188-41-7
7-chloro-5-fluoroquinazolin-2-amine

: 1437787-43-3
C₃₁H₃₇F₂N₅O₅

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / isopropyl alcohol / 2 h / 85 °C / Inert atmosphere

2.1: palladium(II) trifluoroacetate; dicyclohexyl(3-dicyclohexylphosphaniumylpropyl)phosphonium ditetrafluoroborate / 1-methyl-pyrrolidin-2-one / 18 h / 150 °C / Inert atmosphere

2.2: 1 h / 50 °C

2.3: 0.03 h

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

With palladium(II) trifluoroacetate; dicyclohexyl(3-dicyclohexylphosphaniumylpropyl)phosphonium ditetrafluoroborate; triethylamine; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; dichloromethane; isopropyl alcohol;