(1)-4-(1-dodecenyl)-α-phenyl-N-(2,4,6-trimethoxyphenyl)-1H-pyrazole-1-acetamide

Base Information

Chemical Name:(1)-4-(1-dodecenyl)-α-phenyl-N-(2,4,6-trimethoxyphenyl)-1H-pyrazole-1-acetamide
CAS No.:181863-90-1
Molecular Formula:C₃₂H₄₃N₃O₄
Molecular Weight:533.711
Hs Code.:

Synonyms:(1)-4-(1-dodecenyl)-α-phenyl-N-(2,4,6-trimethoxyphenyl)-1H-pyrazole-1-acetamide

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Chemical Property of (1)-4-(1-dodecenyl)-α-phenyl-N-(2,4,6-trimethoxyphenyl)-1H-pyrazole-1-acetamide

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Technology Process of (1)-4-(1-dodecenyl)-α-phenyl-N-(2,4,6-trimethoxyphenyl)-1H-pyrazole-1-acetamide

There total 6 articles about (1)-4-(1-dodecenyl)-α-phenyl-N-(2,4,6-trimethoxyphenyl)-1H-pyrazole-1-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 14227-17-9
2,4,6-trimethoxyaniline

: 181863-89-8
(1)-4-(1-dodecenyl)-α-phenyl-1H-pyrazole-1-acetic acid

: 181863-90-1
(1)-4-(1-dodecenyl)-α-phenyl-N-(2,4,6-trimethoxyphenyl)-1H-pyrazole-1-acetamide

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm9604033

Reference yield: 72.0%

: 102438-99-3
2,4,6-trimethoxyaniline hydrochloride

: 181863-89-8
(1)-4-(1-dodecenyl)-α-phenyl-1H-pyrazole-1-acetic acid

: 181863-90-1
(1)-4-(1-dodecenyl)-α-phenyl-N-(2,4,6-trimethoxyphenyl)-1H-pyrazole-1-acetamide

Guidance literature:: 2,4,6-trimethoxyaniline hydrochloride; With triethylamine; In tetrahydrofuran; for 1h;

(1)-4-(1-dodecenyl)-α-phenyl-1H-pyrazole-1-acetic acid; With dicyclohexyl-carbodiimide; In dichloromethane; at -15 - 20 ℃; for 16h;

Reference yield:

: 2882-19-1,2216-90-2
ethyl 2-phenyl-2-bromoacetate

: 181863-90-1
(1)-4-(1-dodecenyl)-α-phenyl-N-(2,4,6-trimethoxyphenyl)-1H-pyrazole-1-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, 15 min, 2.) THF, RT, 16 h

2: 1.) POCl₃ / 1.) 0 deg C, 30 min, 2.) 70 deg C, 16 h

3: 1.) n-BuLi / 1.) THF, hexanes, -78 deg C, 1 h, 2.) THF, hexanes, RT, 16 h

4: NaOH / aq. ethanol / 1 h

5: 72 percent / DCC / CH₂Cl₂ / 16 h / Ambient temperature

With sodium hydroxide; n-butyllithium; sodium hydride; dicyclohexyl-carbodiimide; trichlorophosphate; In ethanol; dichloromethane;
DOI:10.1021/jm9604033