N²-Benzoyl-O-benzyl-N⁵-(phenylsulfonyl)-2,5-diamino-3-(1-(methoxycarbonyl)-2-oxopropyl)phenol

Base Information

• Chemical Name: N²-Benzoyl-O-benzyl-N⁵-(phenylsulfonyl)-2,5-diamino-3-(1-(methoxycarbonyl)-2-oxopropyl)phenol
• CAS No.: 124400-68-6
• Molecular Formula: C₃₁H₂₈N₂O₇S
• Molecular Weight: 572.639

Synonyms:N²-Benzoyl-O-benzyl-N⁵-(phenylsulfonyl)-2,5-diamino-3-(1-(methoxycarbonyl)-2-oxopropyl)phenol

Chemical Property of N²-Benzoyl-O-benzyl-N⁵-(phenylsulfonyl)-2,5-diamino-3-(1-(methoxycarbonyl)-2-oxopropyl)phenol

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Technology Process of N²-Benzoyl-O-benzyl-N⁵-(phenylsulfonyl)-2,5-diamino-3-(1-(methoxycarbonyl)-2-oxopropyl)phenol

There total 1 articles about N²-Benzoyl-O-benzyl-N⁵-(phenylsulfonyl)-2,5-diamino-3-(1-(methoxycarbonyl)-2-oxopropyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-[4-[(Z)-Benzenesulfonylimino]-2-benzyloxy-cyclohexa-2,5-dien-(Z)-ylidene]-benzamide (112764-62-2) + acetoacetic acid methyl ester (105-45-3) → N2-Benzoyl-O-benzyl-N5-(phenylsulfonyl)-2,5-diamino-4-(1-(methoxycarbonyl)-2-oxopropyl)phenol (124400-69-7) + N2-Benzoyl-O-benzyl-N5-(phenylsulfonyl)-2,5-diamino-3-(1-(methoxycarbonyl)-2-oxopropyl)phenol (124400-68-6)

Guidance literature:

With sodium methylate; In dichloromethane; at -50 ℃; for 18h;

DOI:10.1021/jo00291a059

Reference yield: 71.0%

N2-Benzoyl-O-benzyl-N5-(phenylsulfonyl)-2,5-diamino-3-(1-(methoxycarbonyl)-2-oxopropyl)phenol (124400-68-6) → N5-(Phenylsulfonyl)-5-amino-1-benzoyl-7-(benzyloxy)-2-methylindole-3-carboxylic Acid Methyl Ester (124400-71-1)

Guidance literature:

With sulfuric acid; In dichloromethane;

DOI:10.1021/jo00291a059

Reference yield:

N2-Benzoyl-O-benzyl-N5-(phenylsulfonyl)-2,5-diamino-3-(1-(methoxycarbonyl)-2-oxopropyl)phenol (124400-68-6) → N5,1-Dibenzoyl-N5-(phenylsulfonyl)-5-amino-7-(benzyloxy)-2-methylindole-3-carboxylic Acid Methyl Ester (124400-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / H₂SO₄ (20percent in CH₂Cl₂) / CH₂Cl₂

2: 1) KH / 1) THF, 25 deg C, 0.5 h, 2) 25 deg C, 6 h

With sulfuric acid; potassium hydride; In dichloromethane;

DOI:10.1021/jo00291a059

upstream raw materials:

N-[4-[(Z)-Benzenesulfonylimino]-2-benzyloxy-cyclohexa-2,5-dien-(Z)-ylidene]-benzamide

acetoacetic acid methyl ester

Downstream raw materials:

N⁵-(Phenylsulfonyl)-5-amino-1-benzoyl-7-(benzyloxy)-2-methylindole-3-carboxylic Acid Methyl Ester

N⁵,1-Dibenzoyl-N⁵-(phenylsulfonyl)-5-amino-7-(benzyloxy)-2-methylindole-3-carboxylic Acid Methyl Ester

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