cyclopropyl-[2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indol-9-yl]methanol

Base Information

Chemical Name:cyclopropyl-[2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indol-9-yl]methanol
CAS No.:1022953-20-3
Molecular Formula:C₂₂H₂₄N₂O₄S
Molecular Weight:412.51
Hs Code.:

Synonyms:cyclopropyl-[2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indol-9-yl]methanol

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Chemical Property of cyclopropyl-[2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indol-9-yl]methanol

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Technology Process of cyclopropyl-[2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indol-9-yl]methanol

There total 4 articles about cyclopropyl-[2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indol-9-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1022951-83-2
2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

: 2868-37-3
methyl cyclopropylcarboxylate

: 1022953-20-3
cyclopropyl-[2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indol-9-yl]methanol

Guidance literature:: 2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

methyl cyclopropylcarboxylate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1022953-20-3
cyclopropyl-[2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indol-9-yl]methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C

1.2: 0.5 h

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: -78 - 20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

Reference yield:

: 1953-54-4
indol-5-ol

: 1022953-20-3
cyclopropyl-[2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indol-9-yl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 0.33 h / 50 °C

1.2: 20 °C

2.1: diamide; triphenylphosphine / tetrahydrofuran / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C

3.2: 0.5 h

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

4.2: -78 - 20 °C

With n-butyllithium; diamide; sodium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide;