3,5-Bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propyl)-benzoylamino]-propyl}-benzoic acid ethyl ester

Base Information

Chemical Name:3,5-Bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propyl)-benzoylamino]-propyl}-benzoic acid ethyl ester
CAS No.:349560-00-5
Molecular Formula:C₆₁H₉₂N₆O₁₂
Molecular Weight:1101.43
Hs Code.:

Synonyms:3,5-Bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propyl)-benzoylamino]-propyl}-benzoic acid ethyl ester

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Chemical Property of 3,5-Bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propyl)-benzoylamino]-propyl}-benzoic acid ethyl ester

Chemical Property:

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Technology Process of 3,5-Bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propyl)-benzoylamino]-propyl}-benzoic acid ethyl ester

There total 6 articles about 3,5-Bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propyl)-benzoylamino]-propyl}-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67973-33-5
3,5-dibromobenzoic acid ethyl ester

: 349560-00-5
3,5-Bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propyl)-benzoylamino]-propyl}-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 56 percent / triphenylphosphane / palladium(II) acetate / triethylamine / 168 h / 120 °C

2: 96.5 percent / hydrogen, 25percent HCl / 20percent Pd/C / ethanol; H₂O / 14 h / 2700.2 Torr

3: 94.6 percent / potassium hydroxide / tetrahydrofuran; H₂O / 1 h / 0 °C

4: 88.2 percent / potassium hydroxide / methanol; H₂O / 6 h / 50 °C

5: 1.) hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 2.) ethyldiisopropylamine / 1.) CH₂Cl₂, 0 deg C; 2.) CH₂Cl₂, room temp., 14 h

With hydrogenchloride; potassium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; triethylamine;
DOI:10.1002/(SICI)1099-0690(199807)1998:7<1275::AID-EJOC1275>3.0.CO;2-2

Reference yield:

: 3,5-Bis-((E)-2-cyano-vinyl)-benzoic acid ethyl ester

: 349560-00-5
3,5-Bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propyl)-benzoylamino]-propyl}-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96.5 percent / hydrogen, 25percent HCl / 20percent Pd/C / ethanol; H₂O / 14 h / 2700.2 Torr

2: 94.6 percent / potassium hydroxide / tetrahydrofuran; H₂O / 1 h / 0 °C

3: 88.2 percent / potassium hydroxide / methanol; H₂O / 6 h / 50 °C

4: 1.) hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 2.) ethyldiisopropylamine / 1.) CH₂Cl₂, 0 deg C; 2.) CH₂Cl₂, room temp., 14 h

With hydrogenchloride; potassium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1002/(SICI)1099-0690(199807)1998:7<1275::AID-EJOC1275>3.0.CO;2-2

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 349560-00-5
3,5-Bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propyl)-benzoylamino]-propyl}-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94.6 percent / potassium hydroxide / tetrahydrofuran; H₂O / 1 h / 0 °C

2: 88.2 percent / potassium hydroxide / methanol; H₂O / 6 h / 50 °C

3: 1.) hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 2.) ethyldiisopropylamine / 1.) CH₂Cl₂, 0 deg C; 2.) CH₂Cl₂, room temp., 14 h

With potassium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water;
DOI:10.1002/(SICI)1099-0690(199807)1998:7<1275::AID-EJOC1275>3.0.CO;2-2