3,5-bis{3-[3,5-bis(3-tert-butyloxycarbonylamino-propyl)benzoylamino]propyl}benzoic acid

Base Information

Chemical Name:3,5-bis{3-[3,5-bis(3-tert-butyloxycarbonylamino-propyl)benzoylamino]propyl}benzoic acid
CAS No.:349560-06-1
Molecular Formula:C₅₉H₈₈N₆O₁₂
Molecular Weight:1073.38
Hs Code.:

Synonyms:3,5-bis{3-[3,5-bis(3-tert-butyloxycarbonylamino-propyl)benzoylamino]propyl}benzoic acid

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Chemical Property of 3,5-bis{3-[3,5-bis(3-tert-butyloxycarbonylamino-propyl)benzoylamino]propyl}benzoic acid

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Technology Process of 3,5-bis{3-[3,5-bis(3-tert-butyloxycarbonylamino-propyl)benzoylamino]propyl}benzoic acid

There total 7 articles about 3,5-bis{3-[3,5-bis(3-tert-butyloxycarbonylamino-propyl)benzoylamino]propyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.3%

: 349560-00-5
3,5-Bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propyl)-benzoylamino]-propyl}-benzoic acid ethyl ester

: 349560-06-1
3,5-bis{3-[3,5-bis(3-tert-butyloxycarbonylamino-propyl)benzoylamino]propyl}benzoic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; water; at 50 ℃; for 12h;
DOI:10.1002/(SICI)1099-0690(199807)1998:7<1275::AID-EJOC1275>3.0.CO;2-2

Reference yield:

: 67973-33-5
3,5-dibromobenzoic acid ethyl ester

: 349560-06-1
3,5-bis{3-[3,5-bis(3-tert-butyloxycarbonylamino-propyl)benzoylamino]propyl}benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / triphenylphosphane / palladium(II) acetate / triethylamine / 168 h / 120 °C

2: 96.5 percent / hydrogen, 25percent HCl / 20percent Pd/C / ethanol; H₂O / 14 h / 2700.2 Torr

3: 94.6 percent / potassium hydroxide / tetrahydrofuran; H₂O / 1 h / 0 °C

4: 88.2 percent / potassium hydroxide / methanol; H₂O / 6 h / 50 °C

5: 1.) hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 2.) ethyldiisopropylamine / 1.) CH₂Cl₂, 0 deg C; 2.) CH₂Cl₂, room temp., 14 h

6: 84.3 percent / potassium hydroxide / methanol; H₂O; tetrahydrofuran / 12 h / 50 °C

With hydrogenchloride; potassium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; triethylamine;
DOI:10.1002/(SICI)1099-0690(199807)1998:7<1275::AID-EJOC1275>3.0.CO;2-2

Reference yield:

: 3,5-Bis-((E)-2-cyano-vinyl)-benzoic acid ethyl ester

: 349560-06-1
3,5-bis{3-[3,5-bis(3-tert-butyloxycarbonylamino-propyl)benzoylamino]propyl}benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 96.5 percent / hydrogen, 25percent HCl / 20percent Pd/C / ethanol; H₂O / 14 h / 2700.2 Torr

2: 94.6 percent / potassium hydroxide / tetrahydrofuran; H₂O / 1 h / 0 °C

3: 88.2 percent / potassium hydroxide / methanol; H₂O / 6 h / 50 °C

4: 1.) hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 2.) ethyldiisopropylamine / 1.) CH₂Cl₂, 0 deg C; 2.) CH₂Cl₂, room temp., 14 h

5: 84.3 percent / potassium hydroxide / methanol; H₂O; tetrahydrofuran / 12 h / 50 °C

With hydrogenchloride; potassium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1002/(SICI)1099-0690(199807)1998:7<1275::AID-EJOC1275>3.0.CO;2-2