Furo[3,2-b]pyridine-3-carbonitrile

Base Information

• Chemical Name: Furo[3,2-b]pyridine-3-carbonitrile
• CAS No.: 112372-17-5
• Molecular Formula: C₈H₄N₂O
• Molecular Weight: 144.133
• DSSTox Substance ID: DTXSID90549938
• Nikkaji Number: J433.478G
• Wikidata: Q82429130
• Mol file: 112372-17-5.mol

Synonyms:Furo[3,2-b]pyridine-3-carbonitrile;112372-17-5;Furo[3,2-b]pyridine-3-carbonitrile(9CI);SCHEMBL10861855;DTXSID90549938

Chemical Property of Furo[3,2-b]pyridine-3-carbonitrile

Chemical Property:

• Melting Point: 146-147 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 277.4±20.0 °C(Predicted)
• PKA: 0.99±0.40(Predicted)
• PSA: 49.82000
• Density: 1.31±0.1 g/cm3(Predicted)
• LogP: 1.69948
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 144.032362755
• Heavy Atom Count: 11
• Complexity: 196

Purity/Quality:

Furo[3,2-b]pyridine-3-carbonitrile 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=CO2)C#N)N=C1

Technology Process of Furo[3,2-b]pyridine-3-carbonitrile

There total 1 articles about Furo[3,2-b]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

copper(I) cyanide (544-92-3) + 3-bromofuro<3,2-b>pyridine (92404-63-2) → 3-cyanofuro<3,2-b>pyridine (112372-17-5)

Guidance literature:

In N,N-dimethyl-formamide; for 2h; Heating;

Reference yield: 89.0%

3-cyanofuro<3,2-b>pyridine (112372-17-5) → Furo[3,2-b]pyridine-3-carboxylic acid amide (112372-22-2)

Guidance literature:

With sulfuric acid; water; for 2h; heating on water bath;

Reference yield: 66.0%

3-cyanofuro<3,2-b>pyridine (112372-17-5) → 3-hydroxypyridine-2-acetonitrile (112372-20-0)

Guidance literature:

With potassium hydroxide; In ethanol; for 1h; Heating;

upstream raw materials:

copper(I) cyanide

3-bromofuro<3,2-b>pyridine

Downstream raw materials:

3-hydroxypyridine-2-acetonitrile

Furo[3,2-b]pyridine-3-carboxylic acid amide

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