Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Base Information

• Chemical Name: Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester
• CAS No.: 81244-07-7
• Molecular Formula: C₄₇H₄₇N₂O₁₀PS₂
• Molecular Weight: 895.003
• Mol file: 81244-07-7.mol

Synonyms:Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Chemical Property of Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

There total 5 articles about Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

cyclohexylammonium S,S-diphenyl phosphorodithioate (125292-09-3) + 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-uridine (51296-18-5) → Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester (81244-07-7)

Guidance literature:

With 1,3-dimethoxy-benzene-(sulphonyl)-2,4-disulfonyl chloride; In pyridine; 1.) 30 min; 2.) 15 h;

DOI:10.1016/0040-4020(84)85114-5

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester (81244-07-7)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridinium p-toluenesulphonate / CH₂Cl₂ / 48 h

2: Et₄NBr, KF / acetonitrile; H₂O / 1 h / 55 °C

3: 93 percent / pyridine / 3 h / Ambient temperature

4: 89 percent / 1.) 1,3-dimethoxy-benzene-(sulphonyl)-2,4-disulfonyl chloride / pyridine / 1.) 30 min; 2.) 15 h

With potassium fluoride; 1,3-dimethoxy-benzene-(sulphonyl)-2,4-disulfonyl chloride; tetraethylammonium bromide; pyridinium p-toluenesulfonate; In pyridine; dichloromethane; water; acetonitrile;

DOI:10.1016/0040-4020(84)85114-5

Reference yield:

2'-O-tetrahydropyranyl-5',3'-O-(tetraisopropyldisiloxane-1,3-diyl)uridine (81243-97-2) → Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester (81244-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₄NBr, KF / acetonitrile; H₂O / 1 h / 55 °C

2: 93 percent / pyridine / 3 h / Ambient temperature

3: 89 percent / 1.) 1,3-dimethoxy-benzene-(sulphonyl)-2,4-disulfonyl chloride / pyridine / 1.) 30 min; 2.) 15 h

With potassium fluoride; 1,3-dimethoxy-benzene-(sulphonyl)-2,4-disulfonyl chloride; tetraethylammonium bromide; In pyridine; water; acetonitrile;

DOI:10.1016/0040-4020(84)85114-5

upstream raw materials:

cyclohexylammonium S,S-diphenyl phosphorodithioate

5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-uridine

3,4-dihydro-2H-pyran

2'-O-tetrahydropyranyl-5',3'-O-(tetraisopropyldisiloxane-1,3-diyl)uridine

Downstream raw materials:

C₆₇H₇₀N₄O₁₈P₂S₃

Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[3-(4-methoxy-benzoyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester

S,S-diphenyl 2'-O-(tetrahydropyran-2-yl)-N³-anisoyl-uridine 3'phosphorodithioate

Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine