51296-18-5

Basic information

• Product Name: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(tetrahydro-2H-pyran-2-yl )-
• CAS NO: 51296-18-5
• Molecular Formula: C35H38N2O9
• Molecular Weight: 630.695
• Mol File: 51296-18-5.mol

Chemical Properties

• CAS DataBase Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(tetrahydro-2H-pyran-2-yl )-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(tetrahydro-2H-pyran-2-yl )-(51296-18-5)
• EPA Substance Registry System: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(tetrahydro-2H-pyran-2-yl )-(51296-18-5)

Safety Data

• Hazardous Substances Data: 51296-18-5(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 50826-90-9 O^2'-tetrahydropyran-2-yl-uridine 
• 110-87-2 3,4-dihydro-2H-pyran 
• 81243-97-2 2'-O-tetrahydropyranyl-5',3'-O-(tetraisopropyldisiloxane-1,3-diyl)uridine 
• 58-96-8 uridine 
• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 

Downstream Products

• 2415-43-2 uridylyl-3',5'-uridine 
• 75933-84-5 Phosphoric acid 1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(tetrahydro-pyran-2-yloxy)-ethyl ester 5-chloro-quinolin-8-yl ester 
• 81251-61-8 Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine 
• 81244-13-5 Dithiophosphoric acid O-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester 
• 81243-89-2 C₆₇H₇₀N₄O₁₈P₂S₃ 
• 78462-58-5 Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with pyridine 
• 81244-07-7 Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester 
• 75933-79-8 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-uridine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate) 
• 124814-86-4 Phosphoric acid benzotriazol-1-yl ester (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 

Relevant articles and documents

Application of the Tetraisopropyldisiloxane-1,3-diyl Group in the Chemical Synthesis of Oligoribonucleotides

The application of the tetraisopropyldisiloxane-1,3-diyl (TIPDSi) group for the large-scale preparation of the key components for the chemical synthesis of oligoribonucleotides by the triester approach is described. The key components, N-benzol-2'-O-tetra

SYNTHESIS OF OLIGORIBONUCLEOTIDES BY USE OF S,S-DIPHENYL N-MONOMETHOXYTRITYL RIBONUCLEOSIDE 3'-PHOSPHORODITHIOATES

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A Convenient Synthesis of the 3'-Terminal Nonaoligoribonucleotide of Rous Sarcoma Virus 35S RNA via the Modified Phosphotriester Approach

The synthesis of oligoribonucleotide UpUpCpApCpCpApCpA via the phosphotriester approach, which is located at the 3'terminus of Rous sarcoma virus 35S RNA, is described. 5'-O-(Dimethoxytrityl)-2'-O-tetrahydropyranyl-N-acylnucleoside 3'-(4-chlorophenyl 5-chloro-8-quinolyl phosphates) were used as the starting materials .Treatment of the fully protected mononucleotides with 2percent p-toluenesulfonic acid afforded the 5'-hydroxyl nucleotides, whereas treatment with syn-pyridine-2-carboxaldoxime to remove the 4-chlorophenyl group gave the phosphodiesters.The fully protected nona mer was prepared by utilizing these deblocking products.The fully protected nonamer was completely deprotected by treatment with zinc chloride, followed by treatment with base and acid, to give the corresponding oligoribonucleotide.