1-(4-Cyano-4,4-diphenylbutyl)-4-phenyl-4-piperidinecarboxylic acid, methyl ester

Base Information

Chemical Name:1-(4-Cyano-4,4-diphenylbutyl)-4-phenyl-4-piperidinecarboxylic acid, methyl ester
CAS No.:758672-26-3
Molecular Formula:C₃₀H₃₂N₂O₂
Molecular Weight:452.596
Hs Code.:

Synonyms:1-(4-Cyano-4,4-diphenylbutyl)-4-phenyl-4-piperidinecarboxylic acid, methyl ester

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Chemical Property of 1-(4-Cyano-4,4-diphenylbutyl)-4-phenyl-4-piperidinecarboxylic acid, methyl ester

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Technology Process of 1-(4-Cyano-4,4-diphenylbutyl)-4-phenyl-4-piperidinecarboxylic acid, methyl ester

There total 3 articles about 1-(4-Cyano-4,4-diphenylbutyl)-4-phenyl-4-piperidinecarboxylic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 14078-27-4
α-(3-bromopropyl)-α-phenyl-benzeneacetonitrile

: 54824-07-6
methyl 4-phenylpiperidine-4-carboxylate

: 758672-26-3
1-(4-Cyano-4,4-diphenylbutyl)-4-phenyl-4-piperidinecarboxylic acid, methyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm990316l

Reference yield:

: 86-29-3
Diphenylacetonitrile

: 758672-26-3
1-(4-Cyano-4,4-diphenylbutyl)-4-phenyl-4-piperidinecarboxylic acid, methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / NaH / dimethylformamide / 18 h / 20 °C

2: 47 percent / Cs₂CO₃ / dimethylformamide / 16 h / 20 °C

With sodium hydride; caesium carbonate; In N,N-dimethyl-formamide; 1: Alkylation / 2: Alkylation;
DOI:10.1021/jm990316l