Ethyl 1-ethyl-1,4-dihydro-4-oxo-5-phenyl-3-pyridinecarboxylate

Base Information

Chemical Name:Ethyl 1-ethyl-1,4-dihydro-4-oxo-5-phenyl-3-pyridinecarboxylate
CAS No.:74632-05-6
Molecular Formula:C₁₆H₁₇NO₃
Molecular Weight:271.316
Hs Code.:
DSSTox Substance ID:DTXSID201176690

Synonyms:DTXSID201176690;Ethyl 1-ethyl-1,4-dihydro-4-oxo-5-phenyl-3-pyridinecarboxylate;74632-05-6

Suppliers and Price of Ethyl 1-ethyl-1,4-dihydro-4-oxo-5-phenyl-3-pyridinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 1-ethyl-1,4-dihydro-4-oxo-5-phenyl-3-pyridinecarboxylate

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:271.12084340
Heavy Atom Count:20
Complexity:445

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN1C=C(C(=O)C(=C1)C(=O)OCC)C2=CC=CC=C2

Technology Process of Ethyl 1-ethyl-1,4-dihydro-4-oxo-5-phenyl-3-pyridinecarboxylate

There total 2 articles about Ethyl 1-ethyl-1,4-dihydro-4-oxo-5-phenyl-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.4%

: 78-40-0
triethyl phosphate

: 72676-86-9
ethyl 5-phenyl-4-oxo-1,4-dihydro-3-pyridinecarboxylate

: 74632-05-6
ethyl 1-phenyl-4-oxo-1,4-dihydro-3-pyridinecarboxylate

Guidance literature:: With potassium carbonate; at 170 - 180 ℃; for 0.25h;
DOI:10.1002/jhet.5570170229

Reference yield:

: 718-08-1
ethyl 3-oxo-4-phenylbutyrate

: 74632-05-6
ethyl 1-phenyl-4-oxo-1,4-dihydro-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 53.8 percent / sodium ethoxide / ethanol / 1 h / Heating

2: 77.4 percent / anhydrous potassium carbonate / 0.25 h / 170 - 180 °C

With sodium ethanolate; potassium carbonate; In ethanol;
DOI:10.1002/jhet.5570170229