4-((5S,7R)-7-tert-Butoxy-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenol

Base Information

Chemical Name:4-((5S,7R)-7-tert-Butoxy-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenol
CAS No.:132127-68-5
Molecular Formula:C₂₂H₂₆O₆
Molecular Weight:386.445
Hs Code.:

Synonyms:4-((5S,7R)-7-tert-Butoxy-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenol

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Chemical Property of 4-((5S,7R)-7-tert-Butoxy-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenol

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Technology Process of 4-((5S,7R)-7-tert-Butoxy-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenol

There total 4 articles about 4-((5S,7R)-7-tert-Butoxy-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 132127-59-4,132127-63-0
(5S,7R)-7-(4-Hydroxy-3,5-dimethoxy-phenyl)-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-5-ol

: 75-65-0
tert-butyl alcohol

: 132127-68-5
4-((5S,7R)-7-tert-Butoxy-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenol

Guidance literature:: With boron trifluoride diethyl etherate; at -25 ℃; for 1h;
DOI:10.1021/jm00107a016

Reference yield:

: 132127-61-8
7-(4-Hydroxy-3,5-dimethoxy-phenyl)-6,7-dihydro-indeno[5,6-d][1,3]dioxol-5-one

: 132127-68-5
4-((5S,7R)-7-tert-Butoxy-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / NaBH₄ / methanol; H₂O / 0.5 h / Ambient temperature

2: 20 percent / BF₃*OEt₂ / CH₂Cl₂; tetrahydrofuran; H₂O / 1 h / Ambient temperature

3: 28 percent / BF₃*OEt₂ / 1 h / -25 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00107a016

Reference yield:

: 94671-09-7
6,7-dihydro-7-(3,4,5-trimethoxyphenyl)-5H-indeno<5.6-d>-1,3-dioxol-5-one

: 132127-68-5
4-((5S,7R)-7-tert-Butoxy-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenol

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / trimethylsilyl iodide (TMSI) / CH₂Cl₂ / 6 h / Ambient temperature

2: 75 percent / NaBH₄ / methanol; H₂O / 0.5 h / Ambient temperature

3: 20 percent / BF₃*OEt₂ / CH₂Cl₂; tetrahydrofuran; H₂O / 1 h / Ambient temperature

4: 28 percent / BF₃*OEt₂ / 1 h / -25 °C

With sodium tetrahydroborate; trimethylsilyl iodide; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00107a016