N₁-(2-aminoethyl)-N₂-(tert-butoxycarbonyl)-L-phenylalaninamide

Base Information

• Chemical Name: N₁-(2-aminoethyl)-N₂-(tert-butoxycarbonyl)-L-phenylalaninamide
• CAS No.: 146552-98-9
• Molecular Formula: C₁₆H₂₅N₃O₃
• Molecular Weight: 307.393
• Mol file: 146552-98-9.mol

Synonyms:N₁-(2-aminoethyl)-N₂-(tert-butoxycarbonyl)-L-phenylalaninamide

Chemical Property of N₁-(2-aminoethyl)-N₂-(tert-butoxycarbonyl)-L-phenylalaninamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(2-aminoethyl)-N₂-(tert-butoxycarbonyl)-L-phenylalaninamide

There total 3 articles about N₁-(2-aminoethyl)-N₂-(tert-butoxycarbonyl)-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ N1-(2-aminoethyl)-N2-(tert-butoxycarbonyl)-L-phenylalaninamide (146552-98-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;

Reference yield: 92.0%

(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester (51987-73-6) + ethylenediamine (107-15-3,85404-18-8) → N1-(2-aminoethyl)-N2-(tert-butoxycarbonyl)-L-phenylalaninamide (146552-98-9)

Guidance literature:

In methanol; chloroform; at 20 ℃; Inert atmosphere; Cooling with ice;

DOI:10.1002/cjoc.201090150

Reference yield: 31.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + ethylenediamine (107-15-3,85404-18-8) → N1-(2-aminoethyl)-N2-(tert-butoxycarbonyl)-L-phenylalaninamide (146552-98-9)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h;

DOI:10.1016/j.tetlet.2009.06.047

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

ethylenediamine

(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

Downstream raw materials:

C₃₀H₄₂N₄O₇

C₃₂H₄₃N₅O₆