(2R,R^S)-methyl benzyloxycarbonylamino-3-<(4-methylphenyl)sulfinyl>-2-trifluoromethyl propionate

Base Information

• Chemical Name: (2R,R^S)-methyl benzyloxycarbonylamino-3-<(4-methylphenyl)sulfinyl>-2-trifluoromethyl propionate
• CAS No.: 161083-30-3
• Molecular Formula: C₂₀H₂₀F₃NO₅S
• Molecular Weight: 443.444

Synonyms:(2R,R^S)-methyl benzyloxycarbonylamino-3-<(4-methylphenyl)sulfinyl>-2-trifluoromethyl propionate

Chemical Property of (2R,R^S)-methyl benzyloxycarbonylamino-3-<(4-methylphenyl)sulfinyl>-2-trifluoromethyl propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,R^S)-methyl benzyloxycarbonylamino-3-<(4-methylphenyl)sulfinyl>-2-trifluoromethyl propionate

There total 2 articles about (2R,R^S)-methyl benzyloxycarbonylamino-3-<(4-methylphenyl)sulfinyl>-2-trifluoromethyl propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (triphenyl-λ5-phosphanilidene)carbamate (81357-08-6) → (2R,RS)-methyl benzyloxycarbonylamino-3-<(4-methylphenyl)sulfinyl>-2-trifluoromethyl propionate (161083-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene

2: 1.) LDA / 1.) THF, -60 deg C, 5 min, 2.) THF, -70 deg C, 5 min

With lithium diisopropyl amide; In benzene;

DOI:10.1016/S0957-4166(00)86276-X

Reference yield:

(R)-methyl p-tolyl sulfoxide (1519-39-7) + 2-benzyloxycarbonylimino-3,3,3-trifluoropropionic acid methyl ester (128970-26-3) → (2S,RS)-methyl benzyloxycarbonylamino-3-<(4-methylphenyl)sulfinyl>-2-trifluoromethyl propionate (161083-29-0) + (2R,RS)-methyl benzyloxycarbonylamino-3-<(4-methylphenyl)sulfinyl>-2-trifluoromethyl propionate (161083-30-3)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -60 deg C, 5 min, 2.) THF, -70 deg C, 5 min;

DOI:10.1016/S0957-4166(00)86276-X

Reference yield: 92.6%

(2R,RS)-methyl benzyloxycarbonylamino-3-<(4-methylphenyl)sulfinyl>-2-trifluoromethyl propionate (161083-30-3) → (2R)-methyl 2-benzyloxycarbonylamino-3-<(4-methylphenyl)sulfenyl>-2-trifluoromethyl propionate

Guidance literature:

With trifluoroacetic anhydride; sodium iodide; In acetone; at -20 ℃; for 0.0833333h;

DOI:10.1016/S0957-4166(00)86276-X

upstream raw materials:

(R)-methyl p-tolyl sulfoxide

2-benzyloxycarbonylimino-3,3,3-trifluoropropionic acid methyl ester

benzyl (triphenyl-λ⁵-phosphanilidene)carbamate

Downstream raw materials:

(R)-methyl 2-benzyloxycarbonylamino-2-methyl-3,3,3-trifluoromethyl propionate

(R)-N-(benzyloxycarbonyl)-α-trifluoromethylserine methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 161083-30-3 (2R,R^S)-methyl benzyloxycarbonylamino-3-<(4-methylphenyl)sulfinyl>-2-trifluoromethyl propionate

Send

Send

Metric Ton KG G Pound L ML

Send

Send