3-(4-methoxyphenylimino)-2,2-dimethylpropionic acid ethyl ester

Base Information

• Chemical Name: 3-(4-methoxyphenylimino)-2,2-dimethylpropionic acid ethyl ester
• CAS No.: 874013-30-6
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Mol file: 874013-30-6.mol

Synonyms:3-(4-methoxyphenylimino)-2,2-dimethylpropionic acid ethyl ester

Chemical Property of 3-(4-methoxyphenylimino)-2,2-dimethylpropionic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-(4-methoxyphenylimino)-2,2-dimethylpropionic acid ethyl ester

There total 3 articles about 3-(4-methoxyphenylimino)-2,2-dimethylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3,3-diethoxy-2,2-dimethylpropionic acid ethyl ester (116594-66-2) + 4-methoxy-aniline (104-94-9) → 3-(4-methoxyphenylimino)-2,2-dimethylpropionic acid ethyl ester (874013-30-6)

Guidance literature:

With toluene-4-sulfonic acid; Inert atmosphere;

DOI:10.1002/adsc.200900084

Reference yield:

ethyl 2,2-dimethyl-3-oxopropionate (14002-65-4) + 4-methoxy-aniline (104-94-9) → 3-(4-methoxyphenylimino)-2,2-dimethylpropionic acid ethyl ester (874013-30-6)

Guidance literature:

With magnesium sulfate; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tetasy.2007.08.012

Reference yield:

3,3-diethoxy-2,2-dimethylpropionic acid ethyl ester (116594-66-2) → 3-(4-methoxyphenylimino)-2,2-dimethylpropionic acid ethyl ester (874013-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: CBr₄ / H₂O; acetonitrile / 6 h / 76 °C

2: MgSO₄ / CH₂Cl₂ / 20 °C

With carbon tetrabromide; magnesium sulfate; In dichloromethane; water; acetonitrile;

DOI:10.1016/j.tetasy.2007.08.012

upstream raw materials:

3,3-diethoxy-2,2-dimethylpropionic acid ethyl ester

4-methoxy-aniline

ethyl 2,2-dimethyl-3-oxopropionate