(R)-2-Acetylamino-3-{4-[3-((2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-phenoxy]-phenyl}-propionic acid methyl ester

Base Information

Chemical Name:(R)-2-Acetylamino-3-{4-[3-((2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-phenoxy]-phenyl}-propionic acid methyl ester
CAS No.:126372-78-9
Molecular Formula:C₂₇H₃₃N₃O₆
Molecular Weight:495.576
Hs Code.:

Synonyms:(R)-2-Acetylamino-3-{4-[3-((2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-phenoxy]-phenyl}-propionic acid methyl ester

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Chemical Property of (R)-2-Acetylamino-3-{4-[3-((2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-phenoxy]-phenyl}-propionic acid methyl ester

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Technology Process of (R)-2-Acetylamino-3-{4-[3-((2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-phenoxy]-phenyl}-propionic acid methyl ester

There total 4 articles about (R)-2-Acetylamino-3-{4-[3-((2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-phenoxy]-phenyl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Mn(CO)3C₆H₅(OC₆H₄(CH₂CHCO₂CH₃NHCOCH₃))⁽¹⁺⁾*PF₆^(1-) = {Mn(CO)3(C₆H₅(OC₆H₄(CH₂CHCO₂CH₃NHCOCH₃)))}PF₆

: 87900-18-3,117457-09-7
C₄H₂N₂(OCH₃)2(CH(CH₃)2)Li

: 126372-78-9
(R)-2-Acetylamino-3-{4-[3-((2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-phenoxy]-phenyl}-propionic acid methyl ester

: C₆H₄(OC₆H₄(CH₂CHCO₂CH₃NHCOCH₃))(C₄H₂N₂(OCH₃)2CH(CH₃)2)

Guidance literature:: With N-Bromosuccinimide; In diethyl ether; recat. at -100°C for 2 h, ratio of meta- and ortho-adducts = 10:1;
DOI:10.1039/c39890000659

Reference yield:

: 3410-66-0
D-tyrosine methyl ester

: 126372-78-9
(R)-2-Acetylamino-3-{4-[3-((2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-phenoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent

DOI:10.1021/jo00025a026

Reference yield:

: Na⁽¹⁺⁾*OC₆H₄(CH₂CHCO₂CH₃NHCOCH₃)^(1-) = NaOC₆H₄(CH₂CHCO₂CH₃NHCOCH₃)

: 136889-89-9
(R)-2-Acetylamino-3-{4-[3-((2S,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-phenoxy]-phenyl}-propionic acid methyl ester

: 126372-78-9
(R)-2-Acetylamino-3-{4-[3-((2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-phenoxy]-phenyl}-propionic acid methyl ester

: C₆H₄(OC₆H₄(CH₂CHCO₂CH₃NHCOCH₃))(C₄H₂N₂(OCH₃)2CH(CH₃)2)

Guidance literature:: With N-Bromosuccinimide; Yield given. Multistep reaction. Yields of byproduct given; 1.) acetone, 0 deg C to rt., 10 min; 2.) -100 deg C, 2 h; 3.) Et₂O;
DOI:10.1039/c39890000659