(R)-N-(4-(5,7-dimethyl-4-oxochroman-2-yl)-2-methoxyphenyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:(R)-N-(4-(5,7-dimethyl-4-oxochroman-2-yl)-2-methoxyphenyl)-2,2,2-trifluoroacetamide
CAS No.:1438761-17-1
Molecular Formula:C₂₀H₁₈F₃NO₄
Molecular Weight:393.362
Hs Code.:

Synonyms:(R)-N-(4-(5,7-dimethyl-4-oxochroman-2-yl)-2-methoxyphenyl)-2,2,2-trifluoroacetamide

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Chemical Property of (R)-N-(4-(5,7-dimethyl-4-oxochroman-2-yl)-2-methoxyphenyl)-2,2,2-trifluoroacetamide

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Technology Process of (R)-N-(4-(5,7-dimethyl-4-oxochroman-2-yl)-2-methoxyphenyl)-2,2,2-trifluoroacetamide

There total 2 articles about (R)-N-(4-(5,7-dimethyl-4-oxochroman-2-yl)-2-methoxyphenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1438762-56-1
4-(2,2,2-trifluoroacetamido)-3-methoxyphenylboronic acid

: 67029-85-0
5,7-dimethylchromen-4-one

: 1438761-17-1
(R)-N-(4-(5,7-dimethyl-4-oxochroman-2-yl)-2-methoxyphenyl)-2,2,2-trifluoroacetamide

Guidance literature:: 4-(2,2,2-trifluoroacetamido)-3-methoxyphenylboronic acid; With ammonium hexafluorophosphate; palladium(II) trifluoroacetate; 2-[(S)-4,5-dihydro-4-tert-butyl-1,3-oxazol-2-yl]pyridine; In 1,2-dichloro-ethane; at 20 ℃;

5,7-dimethylchromen-4-one; In water; 1,2-dichloro-ethane; at 60 ℃; for 12h; enantioselective reaction;
DOI:10.1002/chem.201203643

Reference yield:

: 16108-50-2
1-(2-hydroxy-4,6-dimethylphenyl)ethanone

: 1438761-17-1
(R)-N-(4-(5,7-dimethyl-4-oxochroman-2-yl)-2-methoxyphenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: perchloric acid / water / 0.5 h / 20 °C

2.1: 2-[(S)-4,5-dihydro-4-tert-butyl-1,3-oxazol-2-yl]pyridine; palladium(II) trifluoroacetate; ammonium hexafluorophosphate / 1,2-dichloro-ethane / 20 °C

2.2: 12 h / 60 °C

With perchloric acid; ammonium hexafluorophosphate; palladium(II) trifluoroacetate; 2-[(S)-4,5-dihydro-4-tert-butyl-1,3-oxazol-2-yl]pyridine; In water; 1,2-dichloro-ethane;
DOI:10.1002/chem.201203643