1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indole

Base Information

Chemical Name:1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indole
CAS No.:243467-20-1
Molecular Formula:C₂₂H₂₁FN₆
Molecular Weight:388.447
Hs Code.:

Synonyms:1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indole

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Chemical Property of 1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indole

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Technology Process of 1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indole

There total 3 articles about 1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 243467-57-4
1-(4-fluorophenyl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indole

: 34737-83-2
1-methylpiperidin-4-one hydrochloride

: 243467-20-1
1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indole

Guidance literature:: In acetone; trifluoroacetic acid; for 1.5h; Reflux;
DOI:10.1016/j.bmc.2012.10.049

Reference yield:

: 243467-56-3
1-(4-fluorophenyl)-5-(2H-tetrazol-5-yl)-1H-indole

: 243467-20-1
1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; 1-methyl-pyrrolidin-2-one / 2 h / 10 - 20 °C / Inert atmosphere

2: trifluoroacetic acid; acetone / 1.5 h / Reflux

With 1-methyl-pyrrolidin-2-one; potassium tert-butylate; In acetone; trifluoroacetic acid;
DOI:10.1016/j.bmc.2012.10.049

Reference yield:

: 138900-18-2
1-(4-fluorophenyl)-5-cyano-1H-indole

: 243467-20-1
1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine hydrochloride; sodium azide / 1,2-dimethoxyethane / Reflux

2: potassium tert-butylate; 1-methyl-pyrrolidin-2-one / 2 h / 10 - 20 °C / Inert atmosphere

3: trifluoroacetic acid; acetone / 1.5 h / Reflux

With 1-methyl-pyrrolidin-2-one; sodium azide; potassium tert-butylate; triethylamine hydrochloride; In 1,2-dimethoxyethane; acetone; trifluoroacetic acid;
DOI:10.1016/j.bmc.2012.10.049