2-(3,4,5-Trimethoxy-benzyl)-malonic acid bis-(2,2,2-trichloro-ethyl) ester

Base Information

• Chemical Name: 2-(3,4,5-Trimethoxy-benzyl)-malonic acid bis-(2,2,2-trichloro-ethyl) ester
• CAS No.: 149296-17-3
• Molecular Formula: C₁₇H₁₈Cl₆O₇
• Molecular Weight: 547.044
• Mol file: 149296-17-3.mol

Synonyms:2-(3,4,5-Trimethoxy-benzyl)-malonic acid bis-(2,2,2-trichloro-ethyl) ester

Chemical Property of 2-(3,4,5-Trimethoxy-benzyl)-malonic acid bis-(2,2,2-trichloro-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4,5-Trimethoxy-benzyl)-malonic acid bis-(2,2,2-trichloro-ethyl) ester

There total 1 articles about 2-(3,4,5-Trimethoxy-benzyl)-malonic acid bis-(2,2,2-trichloro-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(2,2,2-trichloroethyl) propanedioate (18833-38-0) + 5-(chloromethyl)-1,2,3-trimethoxybenzene (3840-30-0) → 2-(3,4,5-Trimethoxy-benzyl)-malonic acid bis-(2,2,2-trichloro-ethyl) ester (149296-17-3)

Guidance literature:

With sodium hydride; sodium iodide; Yield given. Multistep reaction; 1) THF, 5 min, 2) THF, reflux, 10 h;

DOI:10.1016/S0040-4020(01)80383-5

Reference yield: 100.0%

Dichloromethyl methyl ether (4885-02-3) + 2-(3,4,5-Trimethoxy-benzyl)-malonic acid bis-(2,2,2-trichloro-ethyl) ester (149296-17-3) → 2-(2-Formyl-3,4,5-trimethoxy-benzyl)-malonic acid bis-(2,2,2-trichloro-ethyl) ester (149296-18-4)

Guidance literature:

With tin(IV) chloride; In dichloromethane; a) -78 deg C, 30 min, b) to r.t., 20 min;

DOI:10.1016/S0040-4020(01)80383-5

Reference yield:

2-(3,4,5-Trimethoxy-benzyl)-malonic acid bis-(2,2,2-trichloro-ethyl) ester (149296-17-3) → Bis(2,2,2-trichloroethyl) 2-ethenyl-3,4,5-trimethoxybenzylpropanedioate (117370-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / SnCl₄ / CH₂Cl₂ / a) -78 deg C, 30 min, b) to r.t., 20 min

2: 1) n-BuLi / 1) THF, 2) THF, a) r.t., 6 h, b) reflux, 45 min

With n-butyllithium; tin(IV) chloride; In dichloromethane;

DOI:10.1016/S0040-4020(01)80383-5

upstream raw materials:

bis(2,2,2-trichloroethyl) propanedioate

5-(chloromethyl)-1,2,3-trimethoxybenzene

Downstream raw materials:

2-(2-Formyl-3,4,5-trimethoxy-benzyl)-malonic acid bis-(2,2,2-trichloro-ethyl) ester

Bis(2,2,2-trichloroethyl) 2-ethenyl-3,4,5-trimethoxybenzylpropanedioate

Bis(2,2,2-trichloroethyl) <(5-acetoxy-4-oxo-4H-pyran-2-yl)carbonyl>-(2-ethenyl-3,4,5-trimethoxybenzyl)propanedioate