2-Chloro-1-[2-fluoro-4,5-bis(phenylmethoxy)phenyl]ethanone

Base Information

Chemical Name:2-Chloro-1-[2-fluoro-4,5-bis(phenylmethoxy)phenyl]ethanone
CAS No.:269742-51-0
Molecular Formula:C₂₂H₁₈ClFO₃
Molecular Weight:384.835
Hs Code.:
DSSTox Substance ID:DTXSID001193973

Synonyms:2-chloro-1-[2-fluoro-4,5-bis(phenylmethoxy)phenyl]ethanone;DTXSID001193973;269742-51-0

Suppliers and Price of 2-Chloro-1-[2-fluoro-4,5-bis(phenylmethoxy)phenyl]ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Chloro-1-[2-fluoro-4,5-bis(phenylmethoxy)phenyl]ethanone

Chemical Property:

XLogP3:5.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:384.0928503
Heavy Atom Count:27
Complexity:449

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2=C(C=C(C(=C2)C(=O)CCl)F)OCC3=CC=CC=C3

Technology Process of 2-Chloro-1-[2-fluoro-4,5-bis(phenylmethoxy)phenyl]ethanone

There total 2 articles about 2-Chloro-1-[2-fluoro-4,5-bis(phenylmethoxy)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027163-73-0
2-benzenesulfinyl-1-(4,5-bis-benzyloxy-2-fluoro-phenyl)-2,2-dichloro-ethanol

: 269742-51-0
1-[4,5-bis(benzyloxy)-2-fluorophenyl]-2-chloroethanone

Guidance literature:: With ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -78 - -45 ℃; for 2h;
DOI:10.1021/jm990599h

Reference yield:

: 71924-67-9
4,5-bis(benzyloxy)-2-fluorobenzaldehyde

: 269742-51-0
1-[4,5-bis(benzyloxy)-2-fluorophenyl]-2-chloroethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; cyclohexane / 0.25 h / -78 °C

1.2: tetrahydrofuran; cyclohexane / 1 h / -78 °C

2.1: 560 mg / EtMgBr / tetrahydrofuran; diethyl ether / 2 h / -78 - -45 °C

With ethylmagnesium bromide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; cyclohexane; 1.1: Metallation / 1.2: Addition / 2.1: Elimination;
DOI:10.1021/jm990599h

Reference yield: 85.0%

: 269742-51-0
1-[4,5-bis(benzyloxy)-2-fluorophenyl]-2-chloroethanone

: 269742-52-1
(1R)-1-[4,5-bis(benzyloxy)-2-fluorophenyl]-2-chloroethanol

Guidance literature:: With borane-THF; (R)-proline derived boron compound; In tetrahydrofuran; toluene; at 20 ℃; for 0.166667h;
DOI:10.1021/jm990599h