2-benzenesulfinyl-1-(4,5-bis-benzyloxy-2-fluoro-phenyl)-2,2-dichloro-ethanol

Base Information

Chemical Name:2-benzenesulfinyl-1-(4,5-bis-benzyloxy-2-fluoro-phenyl)-2,2-dichloro-ethanol
CAS No.:1027163-73-0
Molecular Formula:C₂₈H₂₃Cl₂FO₄S
Molecular Weight:545.459
Hs Code.:

Synonyms:2-benzenesulfinyl-1-(4,5-bis-benzyloxy-2-fluoro-phenyl)-2,2-dichloro-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-benzenesulfinyl-1-(4,5-bis-benzyloxy-2-fluoro-phenyl)-2,2-dichloro-ethanol

Chemical Property:

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Technology Process of 2-benzenesulfinyl-1-(4,5-bis-benzyloxy-2-fluoro-phenyl)-2,2-dichloro-ethanol

There total 1 articles about 2-benzenesulfinyl-1-(4,5-bis-benzyloxy-2-fluoro-phenyl)-2,2-dichloro-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71924-67-9
4,5-bis(benzyloxy)-2-fluorobenzaldehyde

: 30058-54-9
α-dichloromethyl phenylsulfoxide

: 1027163-73-0
2-benzenesulfinyl-1-(4,5-bis-benzyloxy-2-fluoro-phenyl)-2,2-dichloro-ethanol

Guidance literature:: α-dichloromethyl phenylsulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.25h;

4,5-bis(benzyloxy)-2-fluorobenzaldehyde; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h; Further stages.;
DOI:10.1021/jm990599h

Reference yield:

: 1027163-73-0
2-benzenesulfinyl-1-(4,5-bis-benzyloxy-2-fluoro-phenyl)-2,2-dichloro-ethanol

: 269742-51-0
1-[4,5-bis(benzyloxy)-2-fluorophenyl]-2-chloroethanone

Guidance literature:: With ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -78 - -45 ℃; for 2h;
DOI:10.1021/jm990599h

Reference yield:

: 1027163-73-0
2-benzenesulfinyl-1-(4,5-bis-benzyloxy-2-fluoro-phenyl)-2,2-dichloro-ethanol

: (1R)-2-amino-1-(3,4-dihydroxy-6-fluorophenyl)ethanol hydrogen oxalate

Guidance literature:: Multi-step reaction with 4 steps

1: 560 mg / EtMgBr / tetrahydrofuran; diethyl ether / 2 h / -78 - -45 °C

2: 85 percent / BH₃*THF; (R)-proline derived boron compound / toluene; tetrahydrofuran / 0.17 h / 20 °C

3: 88 percent / NaN₃; KI / dimethylformamide / 8 h / 110 °C

4: 76 percent / H₂ / 10percent Pd/C / methanol / 24 h / 2327.23 Torr

With sodium azide; borane-THF; (R)-proline derived boron compound; ethylmagnesium bromide; hydrogen; potassium iodide; 10percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; toluene; 1: Elimination / 2: Reduction / 3: Substitution / 4: Catalytic hydrogenation;
DOI:10.1021/jm990599h