[2-(4-azetidin-3-yl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

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Chemical Name:[2-(4-azetidin-3-yl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine
CAS No.:1365990-67-5
Molecular Formula:C₂₀H₁₆Cl₂N₆S
Molecular Weight:443.359
Hs Code.:

Synonyms:[2-(4-azetidin-3-yl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

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Chemical Property of [2-(4-azetidin-3-yl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

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Technology Process of [2-(4-azetidin-3-yl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

There total 10 articles about [2-(4-azetidin-3-yl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1365992-42-2
3-{3,5-dichloro-4-[4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-phenyl}-azetidine-1-carboxylic acid tert-butyl ester

: 1365990-67-5
[2-(4-azetidin-3-yl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

Guidance literature:: 3-{3,5-dichloro-4-[4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-phenyl}-azetidine-1-carboxylic acid tert-butyl ester; In 1,4-dioxane; at 40 ℃; for 1h;

With ammonia; In methanol;

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 1365990-67-5
[2-(4-azetidin-3-yl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2.2: NH₂ cartridge

3.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

4.1: thionyl chloride / 56 h / 90 °C

5.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

5.2: 1.5 h / 90 °C

6.1: chloro-trimethyl-silane; zinc / ISOPROPYLAMIDE; 1,1-Dibromoethane / 2.25 h / Inert atmosphere

6.2: 2 h / 80 °C / Inert atmosphere

7.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 36 h / 85 °C / Inert atmosphere

8.1: 1,4-dioxane / 1 h / 40 °C

With pyridine; chloro-trimethyl-silane; thionyl chloride; diphenyl phosphoryl azide; caesium carbonate; triethylamine; thiourea; trifluoroacetic acid; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1,1-Dibromoethane; dichloromethane; ISOPROPYLAMIDE; isopropyl alcohol; toluene;

Reference yield:

: 1258298-01-9
2,6-dichloro-4-iodo-benzoic acid

: 1365990-67-5
[2-(4-azetidin-3-yl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

3.1: thionyl chloride / 56 h / 90 °C

4.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

4.2: 1.5 h / 90 °C

5.1: chloro-trimethyl-silane; zinc / ISOPROPYLAMIDE; 1,1-Dibromoethane / 2.25 h / Inert atmosphere

5.2: 2 h / 80 °C / Inert atmosphere

6.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 36 h / 85 °C / Inert atmosphere

7.1: 1,4-dioxane / 1 h / 40 °C

With pyridine; chloro-trimethyl-silane; thionyl chloride; caesium carbonate; triethylamine; thiourea; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1,1-Dibromoethane; ISOPROPYLAMIDE; isopropyl alcohol;