6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridine
CAS No.:1095382-65-2
Molecular Formula:C₂₈H₃₃BrN₈
Molecular Weight:561.528
Hs Code.:

Synonyms:6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridine

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Chemical Property of 6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridine

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Technology Process of 6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridine

There total 5 articles about 6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1095382-62-9
tert-butyl 4-(4-(6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)piperazine-1-carboxylate

: 1095382-65-2
6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: C₁₁H₁₇N₃

: 1095382-65-2
6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 h / 45 °C

2: sodium dithionite / ethanol; water; N,N-dimethyl-formamide / 6 h

3: trifluoroacetic acid / dichloromethane

With sodium dithionite; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 63875-01-4
2-methyl-pyridine-4-carbaldehyde

: 1095382-65-2
6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 h / 45 °C

4: sodium dithionite / ethanol; water; N,N-dimethyl-formamide / 6 h

5: trifluoroacetic acid / dichloromethane

With sodium dithionite; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;