63875-01-4

Basic information

• Product Name: 2-METHYLISONICOTINALDEHYDE
• Synonyms: 2-METHYLPYRIDINE-4-CARBALDEHYDE;2-METHYLPYRIDINE-4-CARBOXALDEHYDE;2-METHYLISONICOTINALDEHYDE;4-FORMYL-2-METHYLPYRIDINE;2-Methylisonicotinaldehyde 4-Formyl-2-methylpyridine;2-Methyl-4-pyridinecarbaldehyde;2-Methyl-4-Pyridinecarboxaldehyde;3-forMyl-2-Methylpyridine-4-carboxylic acid
• CAS NO: 63875-01-4
• Molecular Formula: C₇H₇NO
• Molecular Weight: 121.14
• Product Categories: Pyridines;Building Blocks;Pyridine;Heterocycle-Pyridine series
• Mol File: 63875-01-4.mol
• Article Data: 22

Chemical Properties

• Melting Point: 83 °C
• Boiling Point: 210.7 ºC at 760 mmHg
• Flash Point: 85.5 ºC
• Appearance: /
• Density: 1.095 g/cm³
• Vapor Pressure: 0.19mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.98±0.10(Predicted)
• CAS DataBase Reference: 2-METHYLISONICOTINALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLISONICOTINALDEHYDE(63875-01-4)
• EPA Substance Registry System: 2-METHYLISONICOTINALDEHYDE(63875-01-4)

Safety Data

• Hazardous Substances Data: 63875-01-4(Hazardous Substances Data)

Usage

General Description

2-Methylisonicotinaldehyde, also known as 2-methyl-4-pyridinecarboxaldehyde, is a chemical compound with the formula C8H9NO. It is a pale yellow liquid with a strong, aromatic, and nutty odor, and is often used as a flavoring agent in the food industry. It is produced through the reaction of 2-methylpyridine with chloroacetaldehyde, and is commonly found in essential oils and as a component in perfume and fragrance formulations. It is also used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-Methylisonicotinaldehyde is considered to have low toxicity and is generally regarded as safe for use in food and consumer products.

InChI:InChI=1/C7H7NO/c1-6-4-7(5-9)2-3-8-6/h2-5H,1H3

Upstream product

• 108-47-4 2,4-lutidine 
• 2214-53-1 2-methyl-4-cyanopyridine 
• 931-19-1 2-methylpyridine N-oxide 
• 105250-16-6 (2-methylpyridin-4-yl)methanol 
• 444649-52-9 N,N-dimethyl-2-(2-methyl-4-pyridyl)ethenamine 
• 22282-99-1 4-bromo-2-methylpyridine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 899422-63-0 4-chloro-N-{5-chloro-2-[hydroxy-(2-methyl-pyridin-4-yl)-methyl]-pyridin-3-yl}-N-methoxymethyl-3-trifluoromethyl benzenesulfonamide 
• 1095381-68-2 tert-butyl 4-(4-(6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)piperazine-1-carboxylate 
• 1095382-65-2 6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridine 
• 1095381-71-7 6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridine 
• 1095382-67-4 tert-butyl 4-(6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl carbamate 
• 1095381-40-0 2-(4-(6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy)ethanol 
• 1095382-69-6 (4-(6-bromo-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine 
• 1095381-66-0 6-bromo-2-(4-methoxyphenyl)-7-(4-((2-methylpyridin-4-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridine 
• 109942-70-3 3-(2-methylpyridin-4-yl)propan-1-ol 

Relevant articles and documents

Copper-catalyzed selective oxygenation of methyl and benzyl substituents in pyridine with O2

A selective oxygenation of picolines and their derivatives has been achieved by usingasimple copper salt as a catalyst and molecular oxygen as an oxidant, where the α-position of the alkyl substituent is selectively oxidized to give the corresponding aldehydes or ketones. Addition of a catalytic amount of water enhances the catalytic activity, which could be attributed to the role of the proton donor to activate the substrates.

AMINOPYRIMIDINE HETEROCYCLIC COMPOUND WITH ADENOSINE RECEPTOR ANTAGONISTIC ACTIVITY

Disclosed hereinis an aminopyrimidine heterocyclic compound with adenosine receptor antagonistic activity, comprising a compound of the general formula (I), or a pharmaceutically acceptable salt thereof. The aminopyrimidine heterocyclic compound with adenosine receptor antagonistic activitydisclosed herein can be used as an effective adenosine receptor antagonist, and can be used for the treatment or prevention of disorders caused by abnormal level of adenosine.

FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF

The present disclosure relates to Fused Morpholinopyrimidines, pharmaceutical compositions comprising an effective amount of a Fused Morpholinopyrimidine and methods for using a Fused Morpholinopyrimidine in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of a Fused Morpholinopyrimidine.