4-(2-(diphenyloxyphosphoryloxy)ethyl)-4-aza-10-oxatricyclo[5.2.1.0(2,6)]decane-3,5-dione

Base Information

Chemical Name:4-(2-(diphenyloxyphosphoryloxy)ethyl)-4-aza-10-oxatricyclo[5.2.1.0(2,6)]decane-3,5-dione
CAS No.:1338378-73-6
Molecular Formula:C₂₂H₂₂NO₇P
Molecular Weight:443.393
Hs Code.:

Synonyms:4-(2-(diphenyloxyphosphoryloxy)ethyl)-4-aza-10-oxatricyclo[5.2.1.0(2,6)]decane-3,5-dione

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Chemical Property of 4-(2-(diphenyloxyphosphoryloxy)ethyl)-4-aza-10-oxatricyclo[5.2.1.0(2,6)]decane-3,5-dione

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Technology Process of 4-(2-(diphenyloxyphosphoryloxy)ethyl)-4-aza-10-oxatricyclo[5.2.1.0(2,6)]decane-3,5-dione

There total 3 articles about 4-(2-(diphenyloxyphosphoryloxy)ethyl)-4-aza-10-oxatricyclo[5.2.1.0(2,6)]decane-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 245092-42-6,91877-89-3
(3aR,4S,7R,7aS)-2-(2-hydroxyethyl)-3a,4,5,6,7,7a-hexahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 1338378-73-6
4-(2-(diphenyloxyphosphoryloxy)ethyl)-4-aza-10-oxatricyclo[5.2.1.0(2,6)]decane-3,5-dione

Guidance literature:: (3aR,4S,7R,7aS)-2-(2-hydroxyethyl)-3a,4,5,6,7,7a-hexahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione; With di(n-butyl)tin oxide; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

chlorophosphoric acid diphenyl ester; With triethylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.01.031

Reference yield:

: 6118-51-0
exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride

: 1338378-73-6
4-(2-(diphenyloxyphosphoryloxy)ethyl)-4-aza-10-oxatricyclo[5.2.1.0(2,6)]decane-3,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

2.1: triethylamine / toluene / 18 h / Reflux

3.1: di(n-butyl)tin oxide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 18 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; di(n-butyl)tin oxide; triethylamine; In ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.01.031

Reference yield:

: 29745-04-8
norcantharidin

: 1338378-73-6
4-(2-(diphenyloxyphosphoryloxy)ethyl)-4-aza-10-oxatricyclo[5.2.1.0(2,6)]decane-3,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / toluene / 18 h / Reflux

2.1: di(n-butyl)tin oxide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

With di(n-butyl)tin oxide; triethylamine; In dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.01.031