2-{[2-(4-{3-chloro-4-[3-(trifluoromethyl)phenoxy]benzyl}-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl]thio}ethanol

Base Information

Chemical Name:2-{[2-(4-{3-chloro-4-[3-(trifluoromethyl)phenoxy]benzyl}-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl]thio}ethanol
CAS No.:871026-51-6
Molecular Formula:C₂₃H₂₀ClF₃N₄O₂S
Molecular Weight:508.952
Hs Code.:

Synonyms:2-{[2-(4-{3-chloro-4-[3-(trifluoromethyl)phenoxy]benzyl}-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl]thio}ethanol

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Chemical Property of 2-{[2-(4-{3-chloro-4-[3-(trifluoromethyl)phenoxy]benzyl}-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl]thio}ethanol

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Technology Process of 2-{[2-(4-{3-chloro-4-[3-(trifluoromethyl)phenoxy]benzyl}-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl]thio}ethanol

There total 8 articles about 2-{[2-(4-{3-chloro-4-[3-(trifluoromethyl)phenoxy]benzyl}-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl]thio}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₂₄ClF₃N₄O₃S

: 871026-51-6
2-{[2-(4-{3-chloro-4-[3-(trifluoromethyl)phenoxy]benzyl}-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl]thio}ethanol

Guidance literature:: C₃₀H₂₄ClF₃N₄O₃S; With sodium hydroxide; In isopropyl alcohol; at 0 - 20 ℃;

With hydrogenchloride; In water; isopropyl alcohol; Cooling with ice;
DOI:10.1021/jm2008634

Reference yield:

: 871026-53-8
2-{[2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl]thio}ethyl benzoate

: 871026-51-6
2-{[2-(4-{3-chloro-4-[3-(trifluoromethyl)phenoxy]benzyl}-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl]thio}ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropyl alcohol / 15 h / 80 °C

2.1: sodium hydroxide / isopropyl alcohol / 0 - 20 °C

2.2: Cooling with ice

With sodium hydroxide; In isopropyl alcohol;
DOI:10.1021/jm2008634

Reference yield:

: 350-30-1
3-chloro-4-fluoronitrobenzene

: 871026-51-6
2-{[2-(4-{3-chloro-4-[3-(trifluoromethyl)phenoxy]benzyl}-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl]thio}ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: platinum on carbon; hydrogen / ethyl acetate / 2 h / 20 °C

3.1: isopropyl alcohol / 15 h / 80 °C

4.1: sodium hydroxide / isopropyl alcohol / 0 - 20 °C

4.2: Cooling with ice

With platinum on carbon; hydrogen; potassium carbonate; sodium hydroxide; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm2008634