tert-butyl-2-(5-(4-amino-8,9-dimethoxybenzo[c][2,7]naphthyridin-2-yl)pyridin-3-yloxy)ethyl(4-fluorobenzyl)carbamate

Base Information

Chemical Name:tert-butyl-2-(5-(4-amino-8,9-dimethoxybenzo[c][2,7]naphthyridin-2-yl)pyridin-3-yloxy)ethyl(4-fluorobenzyl)carbamate
CAS No.:1055964-22-1
Molecular Formula:C₃₃H₃₄FN₅O₅
Molecular Weight:599.662
Hs Code.:

Synonyms:tert-butyl-2-(5-(4-amino-8,9-dimethoxybenzo[c][2,7]naphthyridin-2-yl)pyridin-3-yloxy)ethyl(4-fluorobenzyl)carbamate

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Chemical Property of tert-butyl-2-(5-(4-amino-8,9-dimethoxybenzo[c][2,7]naphthyridin-2-yl)pyridin-3-yloxy)ethyl(4-fluorobenzyl)carbamate

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Technology Process of tert-butyl-2-(5-(4-amino-8,9-dimethoxybenzo[c][2,7]naphthyridin-2-yl)pyridin-3-yloxy)ethyl(4-fluorobenzyl)carbamate

There total 6 articles about tert-butyl-2-(5-(4-amino-8,9-dimethoxybenzo[c][2,7]naphthyridin-2-yl)pyridin-3-yloxy)ethyl(4-fluorobenzyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4101-30-8
2-amino-4,5-dimethoxyacetophenone

: 1055964-22-1
tert-butyl-2-(5-(4-amino-8,9-dimethoxybenzo[c][2,7]naphthyridin-2-yl)pyridin-3-yloxy)ethyl(4-fluorobenzyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / 10 h / 165 °C / Heating / reflux

2.1: trichlorophosphate / 12 h / Heating / reflux

3.1: potassium carbonate / tetrahydrofuran; water / 6 h

3.2: 10 h / 2585.81 Torr

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C

4.2: 6 h / -78 °C

4.3: -78 - 20 °C

5.1: ammonium acetate / acetic acid / 0.17 h / Heating / reflux

With ammonium acetate; potassium carbonate; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; water; acetic acid;

Reference yield:

: 1055970-97-2
C₃₃H₃₃FN₄O₆

: 1055964-22-1
tert-butyl-2-(5-(4-amino-8,9-dimethoxybenzo[c][2,7]naphthyridin-2-yl)pyridin-3-yloxy)ethyl(4-fluorobenzyl)carbamate

Guidance literature:: C₃₃H₃₃FN₄O₆; With ammonium acetate; In acetic acid; for 0.166667h; Heating / reflux;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1055962-40-7
6,7-dimethoxy-4-methyl-3-cyanoquinoline

: 1055964-22-1
tert-butyl-2-(5-(4-amino-8,9-dimethoxybenzo[c][2,7]naphthyridin-2-yl)pyridin-3-yloxy)ethyl(4-fluorobenzyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C

1.2: 6 h / -78 °C

1.3: -78 - 20 °C

2.1: ammonium acetate / acetic acid / 0.17 h / Heating / reflux

With ammonium acetate; lithium hexamethyldisilazane; In tetrahydrofuran; acetic acid;