(+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione

Base Information

Chemical Name:(+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione
CAS No.:107187-56-4
Molecular Formula:C₂₄H₂₅NO₅S
Molecular Weight:439.532
Hs Code.:

Synonyms:(+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione

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Chemical Property of (+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione

Chemical Property:

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Technology Process of (+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione

There total 10 articles about (+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 102224-24-8
5-[4-(4,6-Dihydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl]thiazolidine-2,4-dione

: 107187-56-4
(+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione

: 134592-16-8
(+/-)-5-<6,7-dihydro-2-hydroxy-1,3,4,6-tetramethyl-6,13-methano-13H-dibenzo<1,4>dioxonin-11-ylmethyl>thiazolidine-2,4-dione

Guidance literature:: With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene; for 10h; Heating;

Reference yield:

: 102224-24-8
5-[4-(4,6-Dihydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl]thiazolidine-2,4-dione

: 107187-56-4
(+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione

Guidance literature:: With sodium hydrogencarbonate; toluene-4-sulfonic acid; In N-methyl-acetamide; water; ethyl acetate; benzene;

Reference yield:

: 700-13-0
Trimethylhydroquinone

: 107187-56-4
(+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: HNTf₂ / CH₂Cl₂

2: DMAP / tetrahydrofuran

3: 60 percent / piperidine / toluene

4: H₂ / Pd/C / methanol

5: aq. HCl; aq. AcOH / methanol

With piperidine; hydrogenchloride; dmap; hydrogen; bis(trifluoromethanesulfonyl)amide; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene; 1: Cycloaddition / 2: Acetylation / 3: Condensation / 4: Hydrogenation / 5: Hydrolysis;
DOI:10.1016/S0960-894X(99)00630-7