(Z)-(4-chlorophenyl)-(5-(4-methylpiperazin-1-yl)oxazol-2-yl)methanone oxime

Base Information

• Chemical Name: (Z)-(4-chlorophenyl)-(5-(4-methylpiperazin-1-yl)oxazol-2-yl)methanone oxime
• CAS No.: 1615228-30-2
• Molecular Formula: C₁₅H₁₇ClN₄O₂
• Molecular Weight: 320.779

Synonyms:(Z)-(4-chlorophenyl)-(5-(4-methylpiperazin-1-yl)oxazol-2-yl)methanone oxime

Chemical Property of (Z)-(4-chlorophenyl)-(5-(4-methylpiperazin-1-yl)oxazol-2-yl)methanone oxime

Chemical Property:

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Technology Process of (Z)-(4-chlorophenyl)-(5-(4-methylpiperazin-1-yl)oxazol-2-yl)methanone oxime

There total 2 articles about (Z)-(4-chlorophenyl)-(5-(4-methylpiperazin-1-yl)oxazol-2-yl)methanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-isocyanoacetyl-N'-methylpiperazine (67685-95-4) + (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride (74903-80-3) → (Z)-(4-chlorophenyl)-(5-(4-methylpiperazin-1-yl)oxazol-2-yl)methanone oxime (1615228-30-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo5005444

Reference yield:

4-chlorobenzaldoxime (3848-36-0) → (Z)-(4-chlorophenyl)-(5-(4-methylpiperazin-1-yl)oxazol-2-yl)methanone oxime (1615228-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chloro-succinimide

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With N-chloro-succinimide; triethylamine; In dichloromethane;

DOI:10.1021/jo5005444

Reference yield:

(Z)-(4-chlorophenyl)-(5-(4-methylpiperazin-1-yl)oxazol-2-yl)methanone oxime (1615228-30-2) → C15H19ClN4O3

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

DOI:10.1021/jo5005444

upstream raw materials:

N-isocyanoacetyl-N'-methylpiperazine

(Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride

4-chlorobenzaldoxime

Downstream raw materials:

2-(4-chlorophenyl)-N-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-2-oxoacetamide

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