5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-(4-methylthiobenzyl)benzoxazole

Base Information

Chemical Name:5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-(4-methylthiobenzyl)benzoxazole
CAS No.:118384-27-3
Molecular Formula:C₁₉H₁₆N₂O₃S₂
Molecular Weight:384.48
Hs Code.:

Synonyms:5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-(4-methylthiobenzyl)benzoxazole

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Chemical Property of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-(4-methylthiobenzyl)benzoxazole

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Technology Process of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-(4-methylthiobenzyl)benzoxazole

There total 5 articles about 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-(4-methylthiobenzyl)benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 16188-55-9
2-(4-(methylthio)phenyl)acetic acid

: 118383-51-0
5-(3-amino-4-hydroxybenzyl)-2,4-thiazolidinedione

: 118384-27-3
5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-(4-methylthiobenzyl)benzoxazole

Guidance literature:: With trimethylsilylphosphate; In 1,2-dichloro-benzene; at 150 ℃; for 1.5h;
DOI:10.1248/cpb.45.1984

Reference yield:

: 621-44-3
3-nitro-L-tyrosine

: 118384-27-3
5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-(4-methylthiobenzyl)benzoxazole

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaNO₂, KBr, aq. 3 N H₂SO₄ / 0.17 h

2: AcONa / ethanol / 3 h / Heating

3: aq. HCl / 2-methoxy-ethanol / 4 h / Heating

4: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 8 h / 760 Torr

5: 65 percent / trimethylsilyl polyphosphate / 1,2-dichloro-benzene / 1.5 h / 150 °C

With hydrogenchloride; trimethylsilylphosphate; sulfuric acid; hydrogen; sodium acetate; potassium bromide; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 2-methoxy-ethanol; 1,2-dichloro-benzene;
DOI:10.1248/cpb.45.1984

Reference yield:

: 118383-65-6
2-bromo-3-(4-hydroxy-3-nitrophenyl)propionic acid

: 118384-27-3
5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-(4-methylthiobenzyl)benzoxazole

Guidance literature:: Multi-step reaction with 4 steps

1: AcONa / ethanol / 3 h / Heating

2: aq. HCl / 2-methoxy-ethanol / 4 h / Heating

3: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 8 h / 760 Torr

4: 65 percent / trimethylsilyl polyphosphate / 1,2-dichloro-benzene / 1.5 h / 150 °C

With hydrogenchloride; trimethylsilylphosphate; hydrogen; sodium acetate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 2-methoxy-ethanol; 1,2-dichloro-benzene;
DOI:10.1248/cpb.45.1984