N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide
CAS No.:1370347-30-0
Molecular Formula:C₁₄H₁₁ClF₃N₅O₄S
Molecular Weight:437.787
Hs Code.:

Synonyms:N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

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Chemical Property of N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

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Technology Process of N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

There total 7 articles about N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 901310-24-5
phenyl (4-methylpyrimidin-2-yl)carbamate

: 1370347-17-3
N-(4-chloro-3-sulfamoylphenyl)-2,2,2-trifluoroacetamide

: 1370347-30-0
N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃;
DOI:10.1016/j.ejmech.2012.01.011

Reference yield:

: 2015-19-2
5-amino-2-chlorobenzenesulfonamide

: 1370347-30-0
N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.ejmech.2012.01.011

Reference yield:

: 96-73-1
2-chloro-5-nitro-benzenesulfonic acid

: 1370347-30-0
N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / water / 1 h / 20 °C

2: chlorosulfonic acid / 4 h / 5 - 130 °C

3: ammonia / water / 10 - 20 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 50 °C

5: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C

With chlorosulfonic acid; palladium 10% on activated carbon; ammonia; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1016/j.ejmech.2012.01.011