Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester
• CAS No.: 350580-89-1
• Molecular Formula: C₃₃H₅₄F₃NO₈SSi₂
• Molecular Weight: 738.026

Synonyms:Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester

Chemical Property of Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester

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Technology Process of Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester

There total 3 articles about Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

trifluoromethylsulfonic anhydride (358-23-6) + [2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene (350580-97-1) → Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester (350580-89-1)

Guidance literature:

With pyridine;

DOI:10.1021/jo0101510

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester (350580-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0 - 20 °C

2: 77 percent / pyridine

With pyridine;

DOI:10.1021/jo0101510

Reference yield:

[2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(RS)-(1,2-dihydroxyethyl)-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]inde → Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester (350580-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0 - 20 °C

2: 77 percent / pyridine

With pyridine;

DOI:10.1021/jo0101510

upstream raw materials:

trifluoromethylsulfonic anhydride

[2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene

t-butyldimethylsiyl triflate

Downstream raw materials:

(1S,2R)-trans-2-phenyl-1-cyclohexanol

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