[2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene

Base Information

• Chemical Name: [2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene
• CAS No.: 350580-97-1
• Molecular Formula: C₃₂H₅₅NO₆Si₂
• Molecular Weight: 605.963

Synonyms:[2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene

Chemical Property of [2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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Useful:

Technology Process of [2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene

There total 1 articles about [2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) + [2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(RS)-(1,2-dihydroxyethyl)-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]inde → [2aS,3R(1R),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(R)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene + [2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene (350580-97-1) + (2aS,3R,6R,7aS,7bR)-3-[1,2-Bis-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]indene

Guidance literature:

With pyridine; at 0 - 20 ℃;

DOI:10.1021/jo0101510

Reference yield: 93.0%

p-toluenesulfonylanhydride (4124-41-8) + [2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene (350580-97-1) → [2aS,3R,6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethyl)dimethylsilyl)oxy]-1-(4-methylbenzenesulfonyl)ethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene (350580-90-4)

Guidance literature:

With pyridine; at 20 ℃; for 0.75h;

DOI:10.1021/jo0101510

Reference yield: 77.0%

trifluoromethylsulfonic anhydride (358-23-6) + [2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene (350580-97-1) → Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester (350580-89-1)

Guidance literature:

With pyridine;

DOI:10.1021/jo0101510

upstream raw materials:

t-butyldimethylsiyl triflate

Downstream raw materials:

Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester

[2aS,3R,6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethyl)dimethylsilyl)oxy]-1-(4-methylbenzenesulfonyl)ethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene

Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester

(1S,2R)-trans-2-phenyl-1-cyclohexanol

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