2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetohydrazide

Base Information

Chemical Name:2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetohydrazide
CAS No.:1638842-87-1
Molecular Formula:C₁₈H₁₇N₅O₃S
Molecular Weight:383.431
Hs Code.:

Synonyms:2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetohydrazide

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Chemical Property of 2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetohydrazide

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Technology Process of 2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetohydrazide

There total 3 articles about 2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1062009-28-2
methyl 2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate

: 1638842-87-1
2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetohydrazide

Guidance literature:: With hydrazine hydrate; In methanol; at 78 ℃; for 4h;
DOI:10.1248/cpb.c14-00158

Reference yield:

: 18741-24-7
3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

: 1638842-87-1
2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 2 h / 25 °C

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / acetonitrile / 10 h / -5 - 20 °C

3: hydrazine hydrate / methanol / 4 h / 78 °C

With benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; ethanol; acetonitrile;
DOI:10.1248/cpb.c14-00158

Reference yield:

: (4-Oxo-3-phenyl-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetic acid methyl ester

: 1638842-87-1
2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; methanol / 3 h / 25 °C

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / acetonitrile / 10 h / -5 - 20 °C

3: hydrazine hydrate / methanol / 4 h / 78 °C

With benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; water; acetonitrile;
DOI:10.1248/cpb.c14-00158