methyl 3-(2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetamido)propanoate

Base Information

Chemical Name:methyl 3-(2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetamido)propanoate
CAS No.:1638842-90-6
Molecular Formula:C₂₂H₂₂N₄O₅S
Molecular Weight:454.506
Hs Code.:

Synonyms:methyl 3-(2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetamido)propanoate

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Chemical Property of methyl 3-(2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetamido)propanoate

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Technology Process of methyl 3-(2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetamido)propanoate

There total 6 articles about methyl 3-(2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₄N₆O₃S

: 3196-73-4
methyl 3-aminopropanoate hydrochloride

: 1638842-90-6
methyl 3-(2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetamido)propanoate

Guidance literature:: With triethylamine; In ethyl acetate; at -5 - 25 ℃; for 48h;
DOI:10.1248/cpb.c14-00158

Reference yield:

: 18741-24-7
3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

: 1638842-90-6
methyl 3-(2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetamido)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / ethanol / 2 h / 25 °C

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / acetonitrile / 10 h / -5 - 20 °C

3: hydrazine hydrate / methanol / 4 h / 78 °C

4: hydrogenchloride; sodium nitrite / water; acetic acid / 1 h / -5 °C

5: triethylamine / ethyl acetate / 48 h / -5 - 25 °C

With hydrogenchloride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; sodium nitrite; In methanol; ethanol; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1248/cpb.c14-00158

Reference yield:

: 30530-97-3
2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetic acid

: 1638842-90-6
methyl 3-(2-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / acetonitrile / 10 h / -5 - 20 °C

2: hydrazine hydrate / methanol / 4 h / 78 °C

3: hydrogenchloride; sodium nitrite / water; acetic acid / 1 h / -5 °C

4: triethylamine / ethyl acetate / 48 h / -5 - 25 °C

With hydrogenchloride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; sodium nitrite; In methanol; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1248/cpb.c14-00158