(R)-3-Hexanoyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-3-(diphenoxy-phosphoryloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonyloxymethyl)-5-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yl ester

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Chemical Name:(R)-3-Hexanoyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-3-(diphenoxy-phosphoryloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonyloxymethyl)-5-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yl ester
CAS No.:252042-39-0
Molecular Formula:C₅₁H₇₆Cl₆NO₁₅PSi
Molecular Weight:1214.94
Hs Code.:

(R)-3-Hexanoyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-3-(diphenoxy-phosphoryloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonyloxymethyl)-5-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yl ester

Synonyms:(R)-3-Hexanoyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-3-(diphenoxy-phosphoryloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonyloxymethyl)-5-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yl ester

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Chemical Property of (R)-3-Hexanoyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-3-(diphenoxy-phosphoryloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonyloxymethyl)-5-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yl ester

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Technology Process of (R)-3-Hexanoyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-3-(diphenoxy-phosphoryloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonyloxymethyl)-5-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yl ester

There total 5 articles about (R)-3-Hexanoyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-3-(diphenoxy-phosphoryloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonyloxymethyl)-5-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2524-64-3
chlorophosphoric acid diphenyl ester

: (R)-3-Hexanoyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-3-hydroxy-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonyloxymethyl)-5-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yl ester

: 252042-39-0
(R)-3-Hexanoyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-3-(diphenoxy-phosphoryloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonyloxymethyl)-5-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yl ester

Guidance literature:: With 2-pyrrolidinopyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/jm990222b

Reference yield:

: 122078-72-2
2-(trimethylsilyl)ethyl 2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranoside

: 252042-39-0
(R)-3-Hexanoyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-3-(diphenoxy-phosphoryloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonyloxymethyl)-5-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / 1 N aq. NaHCO₃ / CHCl₃ / 3 h / 20 °C

2: 4-pyrrolidinopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide methiodide / CH₂Cl₂ / 20 °C

3: 90 percent AcOH / 1 h / 60 °C

4: pyridine / CH₂Cl₂ / 3.5 h / 0 - 20 °C

5: pyrrolidinopyridine; N,N-diisopropylethylamine / CH₂Cl₂ / 5 h / 20 °C

With pyridine; 2-pyrrolidinopyridine; sodium hydrogencarbonate; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; 4-pyrrolidin-1-ylpyridine; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; chloroform; 1: Acylation / 2: Acylation / 3: Hydrolysis / 4: Acylation / 5: phosphorylation;
DOI:10.1021/jm990222b

Reference yield:

: 216013-10-4
2-(trimethylsilil)ethyl 2-deoxy-4,6-O-isopropylidene-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside

: 252042-39-0
(R)-3-Hexanoyloxy-tetradecanoic acid (2R,3S,4R,5R,6R)-3-(diphenoxy-phosphoryloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonyloxymethyl)-5-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4-pyrrolidinopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide methiodide / CH₂Cl₂ / 20 °C

2: 90 percent AcOH / 1 h / 60 °C

3: pyridine / CH₂Cl₂ / 3.5 h / 0 - 20 °C

4: pyrrolidinopyridine; N,N-diisopropylethylamine / CH₂Cl₂ / 5 h / 20 °C

With pyridine; 2-pyrrolidinopyridine; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; 4-pyrrolidin-1-ylpyridine; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1: Acylation / 2: Hydrolysis / 3: Acylation / 4: phosphorylation;
DOI:10.1021/jm990222b