4,4-dimethyl-3-phenyl-5-(((2,2,6,6-tetramethylpiperidin-1-yl)oxy)methyl)-4,5-dihydroisoxazole

Base Information

• Chemical Name: 4,4-dimethyl-3-phenyl-5-(((2,2,6,6-tetramethylpiperidin-1-yl)oxy)methyl)-4,5-dihydroisoxazole
• CAS No.: 1403477-91-7
• Molecular Formula: C₂₁H₃₂N₂O₂
• Molecular Weight: 344.497
• Mol file: 1403477-91-7.mol

Synonyms:4,4-dimethyl-3-phenyl-5-(((2,2,6,6-tetramethylpiperidin-1-yl)oxy)methyl)-4,5-dihydroisoxazole

Chemical Property of 4,4-dimethyl-3-phenyl-5-(((2,2,6,6-tetramethylpiperidin-1-yl)oxy)methyl)-4,5-dihydroisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4-dimethyl-3-phenyl-5-(((2,2,6,6-tetramethylpiperidin-1-yl)oxy)methyl)-4,5-dihydroisoxazole

There total 6 articles about 4,4-dimethyl-3-phenyl-5-(((2,2,6,6-tetramethylpiperidin-1-yl)oxy)methyl)-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2-dimethyl-1-phenylbut-3-en-1-one oxime + 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) → 4,4-dimethyl-3-phenyl-5-(((2,2,6,6-tetramethylpiperidin-1-yl)oxy)methyl)-4,5-dihydroisoxazole (1403477-91-7)

Guidance literature:

With tert.-butylhydroperoxide; N,N,N',N'',N'''-pentamethyldiethylenetriamine; copper(l) cyanide; In water; acetonitrile; at 20 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.7b00826

Reference yield: 92.0%

2,2-dimethyl-1-phenylbut-3-en-1-one oxime + 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + 1-Phenylethynyl-1H-1λ3-benzo[d][1,2]iodoxol-3-one → 4,4-dimethyl-3-phenyl-5-(((2,2,6,6-tetramethylpiperidin-1-yl)oxy)methyl)-4,5-dihydroisoxazole (1403477-91-7) + 4,4-dimethyl-3-phenyl-5-(3-phenylprop-2-yn-1-yl)-4,5-dihydroisoxazole

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 100 ℃; for 1h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01004

Reference yield: 90.0%

2,2-dimethyl-1-phenylbut-3-en-1-one oxime + tert.-butylnitrite (540-80-7) + 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) → 4,4-dimethyl-3-phenyl-5-(((2,2,6,6-tetramethylpiperidin-1-yl)oxy)methyl)-4,5-dihydroisoxazole (1403477-91-7)

Guidance literature:

In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/ol502258n

upstream raw materials:

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

2,2-dimethyl-1-phenylbut-3-en-1-ol

benzaldehyde

prenyl bromide