tert-butyl 4-[5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)-2-pyridinyl]-1-piperazinecarboxylate

Base Information

Chemical Name:tert-butyl 4-[5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)-2-pyridinyl]-1-piperazinecarboxylate
CAS No.:1188335-25-2
Molecular Formula:C₂₆H₃₂FN₅O₅
Molecular Weight:513.569
Hs Code.:

Synonyms:tert-butyl 4-[5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)-2-pyridinyl]-1-piperazinecarboxylate

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Chemical Property of tert-butyl 4-[5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)-2-pyridinyl]-1-piperazinecarboxylate

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Technology Process of tert-butyl 4-[5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)-2-pyridinyl]-1-piperazinecarboxylate

There total 1 articles about tert-butyl 4-[5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)-2-pyridinyl]-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 504437-66-5
(S)‐N‐((3‐(3‐fluoro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)‐2‐oxooxazolidin‐5‐yl)methyl)acetamide

: 153747-97-8
5-Bromo-2-(4-tert-butoxycarbonylpiperazin-1-yl)pyridine

: 1188335-25-2
tert-butyl 4-[5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)-2-pyridinyl]-1-piperazinecarboxylate

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; N,N-dimethyl-formamide; toluene; at 90 ℃; for 1h; Inert atmosphere;

Reference yield: 58.0%

: 1188335-25-2
tert-butyl 4-[5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)-2-pyridinyl]-1-piperazinecarboxylate

: 380381-49-7
N-[((5S)-3-{3-fluoro-4-[6-(1-piperazinyl)-3-pyridinyl]-phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide

Guidance literature:: tert-butyl 4-[5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)-2-pyridinyl]-1-piperazinecarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With sodium hydroxide; In water; ethyl acetate;

Reference yield:

: 1188335-25-2
tert-butyl 4-[5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)-2-pyridinyl]-1-piperazinecarboxylate

: 1188918-41-3
N-({(5S)-3-[3-fluoro-4-(6-{4-[(2-methyl-6-nitro-2,3-dihydro-imidazo[2,1-b][1,3]oxazol-2-yl)methyl]-1-piperazinyl}-3-pyridinyl)-phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 2-ethoxy-ethanol / 2.5 h / Reflux

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 2-ethoxy-ethanol; dichloromethane;