Tert-butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate
CAS No.:153747-97-8
Molecular Formula:C14H20 Br N3 O2
Molecular Weight:342.236
Hs Code.:2933990090
European Community (EC) Number:626-359-9
DSSTox Substance ID:DTXSID10459984
Nikkaji Number:J1.982.167F
Wikidata:Q82283882
Mol file:153747-97-8.mol

Synonyms:153747-97-8;Tert-butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate;4-Boc-1-(5-bromo-2-pyridyl)piperazine;2-(4-BOC-piperazino)-5-bromopyridine;5-Bromo-2-(4-tert-butoxycarbonylpiperazin-1-yl)pyridine;4-(5-Bromo-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester;MFCD07369772;4-(5-Bromopyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester;5-Bromo-2-[4-(N-boc)piperazin-1-yl]pyridine;Palbociclib Impurity 6;SCHEMBL594352;DTXSID10459984;DSLVSFMWCDGZIL-UHFFFAOYSA-N;CS-M2405;EX-A3898;AKOS013100757;AB32239;AM86656;DS-9784;1-Piperazinecarboxylic acid, 4-(5-bromo-2-pyridinyl)-, 1,1-dimethylethyl ester;SY101561;4-Boc-1-(5-Bromopyridin-2-yl)piperazine;4-Boc-1-(5-bromo-2-pyridyl)piperazine, 97%;EN300-3408214;A883792;W-205748;2-[4-(tert-Butoxycarbonyl)piperazino]-5-bromopyridine;tert-Butyl 4-(5-bromo-2-pyridinyl)-1-piperazinecarboxylate;tert-butyl 4-(5-bromopyridin-2-yl)piperazin-1-carboxylate;Tert-butyl4-(5-bromopyridin-2-yl)piperazine-1-carboxylate;1,1-dimethylethyl 4-(5-bromo-2-pyridyl)-1-piperazinecarboxylate;4-(5-Bromo-pyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

Suppliers and Price of Tert-butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(4-BOC-piperazino)-5-bromopyridine
250mg
$ 55.00

SynQuest Laboratories
tert-Butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate
5 g
$ 394.00

SynQuest Laboratories
tert-Butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate
1 g
$ 109.00

Sigma-Aldrich
4-Boc-1-(5-bromo-2-pyridyl)piperazine 97%
1g
$ 54.20

Sigma-Aldrich
4-Boc-1-(5-bromo-2-pyridyl)piperazine 97%
5g
$ 156.00

Crysdot
tert-Butyl4-(5-bromopyridin-2-yl)piperazine-1-carboxylate 98%
25g
$ 143.00

Chemenu
tert-Butyl4-(5-bromopyridin-2-yl)piperazine-1-carboxylate 98%
25g
$ 122.00

Apolloscientific
tert-Butyl4-(5-bromopyridin-2-yl)piperazine-1-carboxylate
5g
$ 357.00

Apolloscientific
tert-Butyl4-(5-bromopyridin-2-yl)piperazine-1-carboxylate
1g
$ 99.00

AOBChem
5-Bromo-2-(4-tert-butoxycarbonylpiperazin-1-yl)pyridine 97%
25g
$ 137.00

Total 28 raw suppliers

Chemical Property of Tert-butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate

Chemical Property:

Vapor Pressure:1.06E-07mmHg at 25°C
Melting Point:83-87 °C(lit.)
Refractive Index:1.559
Boiling Point:433°Cat760mmHg
PKA:6.06±0.29(Predicted)
Flash Point:215.6°C
PSA：45.67000
Density:1.372g/cm³
LogP:2.90410
Storage Temp.:Sealed in dry,Room Temperature
Water Solubility.:Soluble in water.
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:341.07389
Heavy Atom Count:20
Complexity:338

Purity/Quality:

99%, ^*data from raw suppliers

2-(4-BOC-piperazino)-5-bromopyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25-36/37/38
Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCN(CC1)C2=NC=C(C=C2)Br
Uses 4-Boc-1-(5-bromo-2-pyridyl)piperazine is used as active pharmaceutical ingredient.

Technology Process of Tert-butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate

There total 9 articles about Tert-butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 624-28-2
2,5-dibromopyridine

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 153747-97-8
5-Bromo-2-(4-tert-butoxycarbonylpiperazin-1-yl)pyridine

Guidance literature:: With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 100 ℃; for 3h;
DOI:10.1021/ol0357696