1-<3-(methylsulfonyl)phenyl>-3-n-butyl-4-acetoxy-1,8-naphthyridin-2(1H)-one

Base Information

Chemical Name:1-<3-(methylsulfonyl)phenyl>-3-n-butyl-4-acetoxy-1,8-naphthyridin-2(1H)-one
CAS No.:115891-91-3
Molecular Formula:C₂₁H₂₂N₂O₅S
Molecular Weight:414.482
Hs Code.:

Synonyms:1-<3-(methylsulfonyl)phenyl>-3-n-butyl-4-acetoxy-1,8-naphthyridin-2(1H)-one

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Chemical Property of 1-<3-(methylsulfonyl)phenyl>-3-n-butyl-4-acetoxy-1,8-naphthyridin-2(1H)-one

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Technology Process of 1-<3-(methylsulfonyl)phenyl>-3-n-butyl-4-acetoxy-1,8-naphthyridin-2(1H)-one

There total 8 articles about 1-<3-(methylsulfonyl)phenyl>-3-n-butyl-4-acetoxy-1,8-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 89109-07-9
1-<3-(methylsulfinyl)phenyl>-3-n-butyl-4-acetoxy-1,8-naphthyridin-2(1H)-one

: 115891-91-3
1-<3-(methylsulfonyl)phenyl>-3-n-butyl-4-acetoxy-1,8-naphthyridin-2(1H)-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1.) 0 deg C, 0.5 h, 2.) room temperature, 4 h;
DOI:10.1021/jm00119a010

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 115891-91-3
1-<3-(methylsulfonyl)phenyl>-3-n-butyl-4-acetoxy-1,8-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent

2: triethylamine / acetone / 1.) 0 deg C, 2.) heating, 18 h

3: 96 percent / triethylamine / methanol / 6 h / Heating

4: 89 percent / potassium tert-butoxide / 1.) 0.25 h, 2.) heating, 4 h

5: 99 percent / benzene / 24 h / Heating

6: 72 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) room temperature, 4 h

7: 93 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) room temperature, 4 h

With potassium tert-butylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; acetone; benzene;
DOI:10.1021/jm00119a010

Reference yield:

: 1783-81-9
3-methylmercaptoaniline

: 115891-91-3
1-<3-(methylsulfonyl)phenyl>-3-n-butyl-4-acetoxy-1,8-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent

2: triethylamine / acetone / 1.) 0 deg C, 2.) heating, 18 h

3: 96 percent / triethylamine / methanol / 6 h / Heating

4: 89 percent / potassium tert-butoxide / 1.) 0.25 h, 2.) heating, 4 h

5: 99 percent / benzene / 24 h / Heating

6: 72 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) room temperature, 4 h

7: 93 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) room temperature, 4 h

With potassium tert-butylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; acetone; benzene;
DOI:10.1021/jm00119a010