1-(ethoxycarbonyldiazomethyl)-2-phenylisopropyl alcohol

Base Information

• Chemical Name: 1-(ethoxycarbonyldiazomethyl)-2-phenylisopropyl alcohol
• CAS No.: 85515-80-6
• Molecular Formula: C₁₃H₁₆N₂O₃
• Molecular Weight: 248.282
• Mol file: 85515-80-6.mol

Synonyms:1-(ethoxycarbonyldiazomethyl)-2-phenylisopropyl alcohol

Chemical Property of 1-(ethoxycarbonyldiazomethyl)-2-phenylisopropyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-(ethoxycarbonyldiazomethyl)-2-phenylisopropyl alcohol

There total 1 articles about 1-(ethoxycarbonyldiazomethyl)-2-phenylisopropyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

diazoacetic acid ethyl ester (623-73-4) + 1-phenyl-acetone (103-79-7,136675-26-8) → 1-(ethoxycarbonyldiazomethyl)-2-phenylisopropyl alcohol (85515-80-6)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃;

DOI:10.1021/ja950971s

Reference yield: 30.0%

1-(ethoxycarbonyldiazomethyl)-2-phenylisopropyl alcohol (85515-80-6) → ethyl 2-methyl-3-oxo-4-phenylbutanoate (2867-62-1) + 3-methyl-1H-indene-2-carboxylic acid ethyl ester (118215-65-9) + Ethyl 2-benzylacetoacetate (620-79-1) + (Z)-3-Acetylamino-2-benzyl-but-2-enoic acid ethyl ester

Guidance literature:

With boron trifluoride diethyl etherate; acetonitrile; at 0 ℃; for 0.166667h; Further byproducts given. Title compound not separated from byproducts;

DOI:10.1021/ja950971s

Reference yield: 30.0%

1-(ethoxycarbonyldiazomethyl)-2-phenylisopropyl alcohol (85515-80-6) → 3-methyl-1H-indene-2-carboxylic acid ethyl ester (118215-65-9) + Ethyl 2-benzylacetoacetate (620-79-1) + (Z)-3-Acetylamino-2-benzyl-but-2-enoic acid ethyl ester + ethyl 2-methyl-1H-indene-3-carboxylate

Guidance literature:

With boron trifluoride diethyl etherate; acetonitrile; at 0 ℃; for 0.166667h; Further byproducts given. Title compound not separated from byproducts;

DOI:10.1021/ja950971s

upstream raw materials:

diazoacetic acid ethyl ester

1-phenyl-acetone

Downstream raw materials:

3-methyl-1H-indene-2-carboxylic acid ethyl ester

Ethyl 2-benzylacetoacetate

3-methyl-4-phenylfuran-2(5H)-one

ethyl 2-methyl-3-oxo-4-phenylbutanoate

Refernces