N-(4-Fluoro-phenyl)-3-methyl-2-{(3aR,7aS)-4-oxo-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-2-yl}-butyramide

Base Information

Chemical Name:N-(4-Fluoro-phenyl)-3-methyl-2-{(3aR,7aS)-4-oxo-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-2-yl}-butyramide
CAS No.:1412906-13-8
Molecular Formula:C₂₆H₂₉F₄N₃O₃
Molecular Weight:507.528
Hs Code.:

Synonyms:N-(4-Fluoro-phenyl)-3-methyl-2-{(3aR,7aS)-4-oxo-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-2-yl}-butyramide

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Chemical Property of N-(4-Fluoro-phenyl)-3-methyl-2-{(3aR,7aS)-4-oxo-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-2-yl}-butyramide

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Technology Process of N-(4-Fluoro-phenyl)-3-methyl-2-{(3aR,7aS)-4-oxo-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-2-yl}-butyramide

There total 10 articles about N-(4-Fluoro-phenyl)-3-methyl-2-{(3aR,7aS)-4-oxo-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-2-yl}-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 5-[4-(2,2,2-Trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one

: 923121-94-2
C₁₁H₁₃BrFNO

: 1412906-13-8
N-(4-Fluoro-phenyl)-3-methyl-2-{(3aR,7aS)-4-oxo-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-2-yl}-butyramide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃;

Reference yield:

: 923121-94-2
C₁₁H₁₃BrFNO

: 1412905-96-4
5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one

: 1412906-13-8
N-(4-Fluoro-phenyl)-3-methyl-2-{(3aR,7aS)-4-oxo-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-2-yl}-butyramide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃;

Reference yield:

: 1412905-93-1
N-But-3-enyl-N-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-acrylamide

: 1412906-13-8
N-(4-Fluoro-phenyl)-3-methyl-2-{(3aR,7aS)-4-oxo-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-2-yl}-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: Grubbs catalyst / dichloromethane / 45 °C

2: trifluoroacetic acid / dichloromethane / 30 h / 45 °C

3: hydrogen / palladium on carbon / methanol / 3 h / 20 °C

4: hydrogenchloride / ethyl acetate / 1.5 h

5: potassium carbonate / N,N-dimethyl-formamide / 85 °C

With hydrogenchloride; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;