2-BENZYL ACRYLIC ACID TER-BUTYL ESTER

Base Information

• Chemical Name: 2-BENZYL ACRYLIC ACID TER-BUTYL ESTER
• CAS No.: 111832-40-7
• Molecular Formula: C14H18 O2
• Molecular Weight: 218.29
• Mol file: 111832-40-7.mol

Synonyms:2-Benzylacrylicacid tert-butyl ester; tert-Butyl 2-benzylacrylate

Chemical Property of 2-BENZYL ACRYLIC ACID TER-BUTYL ESTER

Chemical Property:

• Boiling Point: 300.8±21.0 °C(Predicted)
• PSA: 26.30000
• Density: 0.993±0.06 g/cm3(Predicted)
• LogP: 3.12700

Purity/Quality:

99%min ^*data from raw suppliers

TERT-BUTYL-2-BENZYL ACRYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BENZYL ACRYLIC ACID TER-BUTYL ESTER

There total 6 articles about 2-BENZYL ACRYLIC ACID TER-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-Benzyl-2-propenoic acid (5669-19-2) → 1-(tert-butoxycarbonyl)-1-benzylethene (111832-40-7)

Guidance literature:

With dmap; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1039/d1ob01306h

Reference yield: 80.0%

tert-butyl 2-(bromomethyl)acrylate (53913-96-5) + C7H5CuN(1-)*I(1-)*Zn(2+) → 1-(tert-butoxycarbonyl)-1-benzylethene (111832-40-7)

Guidance literature:

In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/S0040-4039(00)97635-4

Reference yield:

tert-Butyl methacrylate (585-07-9,25189-00-8) + phenylboronic acid (98-80-6) → 1-(tert-butoxycarbonyl)-1-benzylethene (111832-40-7) + (Z)-tert-butyl α-methylcinnamate (98831-00-6,98831-01-7)

Guidance literature:

With 2.9-dimethyl-1,10-phenanthroline; oxygen; palladium diacetate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Title compound not separated from byproducts;

DOI:10.1021/ja063710z

upstream raw materials:

tert-butyl 2-(bromomethyl)acrylate

tert-Butyl methacrylate

phenylboronic acid

benzaldehyde

Refernces

• 1、 Ramachary, Dhevalapally B.,Venkaiah, Chintalapudi,Reddy, Y. Vijayendar. "High-yielding sequential one-pot synthesis of chiral and achiral α-substituted acrylates via a metal-free reductive coupling reaction". . p. 5400 - 5406. Retrieved 2014/07/21.
• 2、 -. "Matrix metalloprotease inhibitors". . . Retrieved 2012/01/30.