1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

Base Information

Chemical Name:1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole
CAS No.:228259-17-4
Molecular Formula:C₁₆H₁₂F₃N₅O₂
Molecular Weight:363.299
Hs Code.:

Synonyms:1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

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Chemical Property of 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

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Technology Process of 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

There total 8 articles about 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 228259-15-2
methanesulfonic acid 2-(5-furan-2-yl-3-trifluoromethyl-pyrazol-1-yl)-5-methoxy-benzyl ester

: 228259-17-4
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.1021/jm030212h

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 228259-17-4
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1: AcOH / 4 h / 100 °C

2: N-methylmorpholine / tetrahydrofuran / 0.5 h / 0 °C

3: 1.5 g / NaBH₄ / tetrahydrofuran; H₂O

4: Et₃N / CHCl₃ / 4 h / cooling

5: 1.43 g / NaN₃ / dimethylformamide / 2 h / 60 °C

With 4-methyl-morpholine; sodium tetrahydroborate; sodium azide; acetic acid; triethylamine; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm030212h

Reference yield:

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 228259-17-4
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: HCl; NaNO₂ / H₂O / 0.5 h / 0 °C

1.2: SnCl₂*2H₂O; HCl / H₂O / 3 h / 0 - 20 °C

2.1: AcOH / 4 h / 100 °C

3.1: N-methylmorpholine / tetrahydrofuran / 0.5 h / 0 °C

4.1: 1.5 g / NaBH₄ / tetrahydrofuran; H₂O

5.1: Et₃N / CHCl₃ / 4 h / cooling

6.1: 1.43 g / NaN₃ / dimethylformamide / 2 h / 60 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; sodium azide; acetic acid; triethylamine; sodium nitrite; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm030212h