1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2-fluoro-4-(2-N-tert-butylaminosulfonyl)-[1,1]-biphen-4-yl))carboxamide

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Chemical Name:1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2-fluoro-4-(2-N-tert-butylaminosulfonyl)-[1,1]-biphen-4-yl))carboxamide
CAS No.:228259-20-9
Molecular Formula:C₂₉H₂₇F₄N₇O₄S
Molecular Weight:645.637
Hs Code.:

Synonyms:1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2-fluoro-4-(2-N-tert-butylaminosulfonyl)-[1,1]-biphen-4-yl))carboxamide

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Chemical Property of 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2-fluoro-4-(2-N-tert-butylaminosulfonyl)-[1,1]-biphen-4-yl))carboxamide

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Technology Process of 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2-fluoro-4-(2-N-tert-butylaminosulfonyl)-[1,1]-biphen-4-yl))carboxamide

There total 12 articles about 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2-fluoro-4-(2-N-tert-butylaminosulfonyl)-[1,1]-biphen-4-yl))carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 209919-51-7
(2'-tert-butylaminosulfonyl-3-fluoro-[1,1']-biphen-4-yl)amine

: 228259-19-6
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride

: 228259-20-9
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2-fluoro-4-(2-N-tert-butylaminosulfonyl)-[1,1]-biphen-4-yl))carboxamide

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm030212h

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 228259-20-9
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2-fluoro-4-(2-N-tert-butylaminosulfonyl)-[1,1]-biphen-4-yl))carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: AcOH / 4 h / 100 °C

2: N-methylmorpholine / tetrahydrofuran / 0.5 h / 0 °C

3: 1.5 g / NaBH₄ / tetrahydrofuran; H₂O

4: Et₃N / CHCl₃ / 4 h / cooling

5: 1.43 g / NaN₃ / dimethylformamide / 2 h / 60 °C

6: 68 percent / potassium permanganate / acetone; H₂O / 3 h / 60 °C

7: oxalyl chloride; DMF / CH₂Cl₂ / 3 h / 0 °C

8: 0.28 g / pyridine; DMAP / CH₂Cl₂ / 18 h / 20 °C

With 4-methyl-morpholine; pyridine; dmap; sodium tetrahydroborate; potassium permanganate; sodium azide; oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm030212h

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 228259-20-9
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2-fluoro-4-(2-N-tert-butylaminosulfonyl)-[1,1]-biphen-4-yl))carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; H₂O / 18 h / Heating

2: 0.28 g / pyridine; DMAP / CH₂Cl₂ / 18 h / 20 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm030212h