(2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrothiophene

Base Information

Chemical Name:(2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrothiophene
CAS No.:142941-51-3
Molecular Formula:C₁₃H₁₈O₄S₂
Molecular Weight:302.416
Hs Code.:

Synonyms:(2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrothiophene

Suppliers and Price of (2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrothiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrothiophene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrothiophene

There total 16 articles about (2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 132813-66-2,132881-85-7
(3S,5R)-5-<(benzyloxy)methyl>tetrahydrothiophen-3-ol

: 124-63-0
methanesulfonyl chloride

: 142941-51-3
(2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrothiophene

Guidance literature:: With dmap; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 132813-61-7,132813-62-8,142941-63-7,142941-64-8
(3R,5S)-5-Benzyloxymethyl-2-methoxy-tetrahydro-furan-3-ol

: 142941-51-3
(2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrothiophene

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / DMAP / CH₂Cl₂ / 1 h / 0 °C

2: 90 percent / CF₃COOH / H₂O; tetrahydrofuran / 5 h

3: 83 percent / NaBH(OAc)3 / toluene / 0.75 h / 80 °C

4: 90 percent / pyridine / CH₂Cl₂ / 18 h / 4 °C

5: 73 percent / Na₂S / dimethylformamide / 3 h / 100 °C

6: 82 percent / diethyl azodicarboxylate, PPh₃ / tetrahydrofuran / 0.83 h / Ambient temperature

7: 81 percent / K₂CO₃ / methanol / 0.5 h

8: 94 percent / DMAP / CH₂Cl₂ / 1 h / 0 °C

With pyridine; dmap; sodium sulfide; sodium tris(acetoxy)borohydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 142941-49-9
(2R,4S)-2-benzoyloxy-5-(benzyloxy)pentane-1,4-diol

: 142941-51-3
(2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrothiophene

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / pyridine / CH₂Cl₂ / 18 h / 4 °C

2: 73 percent / Na₂S / dimethylformamide / 3 h / 100 °C

3: 82 percent / diethyl azodicarboxylate, PPh₃ / tetrahydrofuran / 0.83 h / Ambient temperature

4: 81 percent / K₂CO₃ / methanol / 0.5 h

5: 94 percent / DMAP / CH₂Cl₂ / 1 h / 0 °C

With pyridine; dmap; sodium sulfide; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;