methyl N-methyl-2-[((4-chlorophenyl)-carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate

Base Information

Chemical Name:methyl N-methyl-2-[((4-chlorophenyl)-carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate
CAS No.:1430212-84-2
Molecular Formula:C₁₇H₁₈ClNO₃S
Molecular Weight:351.854
Hs Code.:

Synonyms:methyl N-methyl-2-[((4-chlorophenyl)-carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate

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Chemical Property of methyl N-methyl-2-[((4-chlorophenyl)-carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate

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Technology Process of methyl N-methyl-2-[((4-chlorophenyl)-carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate

There total 3 articles about methyl N-methyl-2-[((4-chlorophenyl)-carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 544450-68-2
methyl 2-(4-chlorophenylcarboxamido)?4-ethyl-5-methylthiophene-3-carboxylate

: 74-88-4
methyl iodide

: 1430212-84-2
methyl N-methyl-2-[((4-chlorophenyl)-carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate

Guidance literature:: methyl 2-(4-chlorophenylcarboxamido)?4-ethyl-5-methylthiophene-3-carboxylate; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm400144w

Reference yield:

: 4815-25-2
methyl 2-amino-4-ethyl-5-methylthiophene-3-carboxylate

: 1430212-84-2
methyl N-methyl-2-[((4-chlorophenyl)-carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-dioxane / 70 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With potassium tert-butylate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm400144w

Reference yield:

: 96-22-0
pentan-3-one

: 1430212-84-2
methyl N-methyl-2-[((4-chlorophenyl)-carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: morpholine; sulfur / ethanol / Reflux

2.1: 1,4-dioxane / 70 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With morpholine; sulfur; potassium tert-butylate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 1.1: |Gewald Aminoheterocycles Synthesis;
DOI:10.1021/jm400144w