4,6-dichloro-N-(2-hydroxyethyl)-N-(2-phenyl-1-propyl-1H-indol-5-yl)pyrimidine-5-carboxamide

Base Information

Chemical Name:4,6-dichloro-N-(2-hydroxyethyl)-N-(2-phenyl-1-propyl-1H-indol-5-yl)pyrimidine-5-carboxamide
CAS No.:1415345-98-0
Molecular Formula:C₂₄H₂₂Cl₂N₄O₂
Molecular Weight:469.37
Hs Code.:

Synonyms:4,6-dichloro-N-(2-hydroxyethyl)-N-(2-phenyl-1-propyl-1H-indol-5-yl)pyrimidine-5-carboxamide

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Chemical Property of 4,6-dichloro-N-(2-hydroxyethyl)-N-(2-phenyl-1-propyl-1H-indol-5-yl)pyrimidine-5-carboxamide

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Technology Process of 4,6-dichloro-N-(2-hydroxyethyl)-N-(2-phenyl-1-propyl-1H-indol-5-yl)pyrimidine-5-carboxamide

There total 8 articles about 4,6-dichloro-N-(2-hydroxyethyl)-N-(2-phenyl-1-propyl-1H-indol-5-yl)pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1415345-97-9
N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(2-phenyl-1-propyl-1H-indol-5-yl)pyrimidine-5-carboxamide

: 1415345-98-0
4,6-dichloro-N-(2-hydroxyethyl)-N-(2-phenyl-1-propyl-1H-indol-5-yl)pyrimidine-5-carboxamide

Guidance literature:: With hydrogenchloride; water; In methanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 98-80-6
phenylboronic acid

: 1415345-98-0
4,6-dichloro-N-(2-hydroxyethyl)-N-(2-phenyl-1-propyl-1H-indol-5-yl)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: palladium diacetate / acetic acid / 2 h / 25 °C

2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C

3: boron tribromide / dichloromethane / 1 h / 0 °C

4: pyridine / dichloromethane / 1 h / 0 °C / Cooling with ice

5: caesium carbonate; XPhos / palladium diacetate / toluene / 4 h / 111 °C / Inert atmosphere

6: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

7: hydrogenchloride; water / methanol / 2 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; water; boron tribromide; caesium carbonate; triethylamine; XPhos; palladium diacetate; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; 5: buchwald reaction;

Reference yield:

: 1006-94-6
5-methoxylindole

: 1415345-98-0
4,6-dichloro-N-(2-hydroxyethyl)-N-(2-phenyl-1-propyl-1H-indol-5-yl)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: palladium diacetate / acetic acid / 2 h / 25 °C

2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C

3: boron tribromide / dichloromethane / 1 h / 0 °C

4: pyridine / dichloromethane / 1 h / 0 °C / Cooling with ice

5: caesium carbonate; XPhos / palladium diacetate / toluene / 4 h / 111 °C / Inert atmosphere

6: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

7: hydrogenchloride; water / methanol / 2 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; water; boron tribromide; caesium carbonate; triethylamine; XPhos; palladium diacetate; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; 5: buchwald reaction;